Front. Neurol. Frontiers in Neurology Front. Neurol. 1664-2295 Frontiers Media S.A. 10.3389/fneur.2021.614382 Neurology Systematic Review A Meta-Analysis of Endoscopic vs. Microscopic Transsphenoidal Surgery for Non-functioning and Functioning Pituitary Adenomas: Comparisons of Efficacy and Safety Guo Shengfu 1 † Wang Zidong 1 † Kang Xiaokui 1 Xin Wenqiang 2 3 Li Xin 1 * 1Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, China 2Department of Neurology, University Medical Center Goettingen, Göttingen, Germany 3Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China

Edited by: Mahua Dey, University of Wisconsin-Madison, United States

Reviewed by: Matteo Zoli, IRCCS Institute of Neurological Sciences of Bologna (ISNB), Italy; Paweł Sokal, Nicolaus Copernicus University in Toruń, Poland

 *Correspondence: Xin Li lixinliaocheng@163.com

This article was submitted to Neuro-Oncology and Neurosurgical Oncology, a section of the journal Frontiers in Neurology

†These authors have contributed equally to this work and share first authorship

 23 03 2021 2021 12 614382 06 10 2020 23 02 2021 Copyright © 2021 Guo, Wang, Kang, Xin and Li. 2021 Guo, Wang, Kang, Xin and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Background: Although microscopic (MTSS) and endoscopic transsphenoidal surgery (ETSS) are both effective approaches for treating non-functioning pituitary adenomas (NFPA) and functioning pituitary adenomas (FPA), the consensus remains unidentified on whether there are differences in the risk of postoperative complications between the two surgical approaches.

Method: A meta-analysis of the study of MTSS vs. ETSS for NFPA and FPA was conducted by searching the electronic databases of PubMed, Cochrane Library, and EMBASE, from the date of establishment of electronic databases to September 2020 based on the PRISMA guidelines.

Results: In this study, a total of 16 studies were selected, hailing from Belgium, the USA, India, Finland, France, Korea, Spain, China, and Canada. We enrolled 1003 patients in the ETSS and 992 patients in the MTSS group. In patients with NFPA, the ETSS group was related to a higher incidence of post-operative gross-total resection (GTR). (OR = 1.655, 95% CI 1.131–2.421, P = 0.010). In participants with FPA, the results illustrated that the ETSS group had higher rates of visual improvement (OR = 2.461, 95% CI 1.109–5.459) and gross-total resection (OR = 2.033, 95% CI 1.335–3.096), as well as lower meningitis rates (OR = 0.195, 95% CI 0.041–1.923). In participants with acromegaly, no significant difference was shown in the postoperative complications.

Conclusion: Based on current evidence, participants with NFPA treated by endoscopy were related to higher rates of GTR; patients with FPA treated by ETSS were related to higher rates of visual improvement and GTR, as well as a lower rates of meningitis.

 pituitary adenoma non-functioning functioning endoscopic microscopic Introduction

Pituitary adenomas, which contribute to 14% of primary intracranial neoplasms, are the second most common central nervous system tumor. The incidence of pituitary adenomas in the general population has increased to 17% (1, 2). 36–54% of pituitary adenomas are non-functional, while 46–64% of them are hormone-secreting (3–5). Even though a large proportion of pituitary adenomas are histologically benign, due to their location being close to crucial structures and the hypersecretion or paracrisis of the pituitary hormone, they can result in serious endocrine conditions, such as acromegaly and Cushing disease (6).

In the 1960s, Hardy (7) reported an operative microscope for better visualization during transsphenoidal surgery, which enabled the safer removal of sellar tumors. Microscopic transsphenoidal pituitary surgery (MTSS) had at the time been widely performed and became the gold standard. But within the next few years, and with the evolution of endoscopic techniques, by 1992, Jankowski et al. (8) performed fully endoscopic surgery via the endonasal approach for pituitary tumors. Since then, endoscopic transsphenoidal pituitary surgery (ETSS) has increasingly been adopted. Nevertheless, establishing which surgical method is superior in managing pituitary tumors, remains unknown. ETSS enjoys more popularity, attributed to the panoramic view of its surrounding structures and minimal invasiveness, leading to a greater chance of removing central skull base lesions (9, 10). Whereas, ETSS has limitations of two-dimensioned visualization, less focus capacity, and a steep learning curve for neurosurgeons. Furthermore, consensus on whether there are differences in the risk of postoperative complications between the two surgical approaches remains unclear (11).

Recently, several studies on ETSS vs. MTSS has been reported in the literature. We thus set out to perform a meta-analysis to evaluate the postoperative outcomes between ETSS and MTSS, in participants with non-functioning pituitary adenomas (NFPA) or functioning pituitary adenomas (FPA).

 Materials and Methods

The systematic review and meta-analysis of the literature was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) (12).

Literature Search

The search object was research literature on the analysis of all comparative studies of ETSS vs. MTSS for non-functioning and functioning pituitary adenomas published in publicly available electronic databases, including PubMed, Cochrane Library, and EMBASE, from the date of establishment of electronic databases to September 2020. To obtain maximum results in identifying relevant literature, the following literature search keywords were adopted: “transsphenoidal surgery,” “pituitary,” “non-functioning,” “functioning,” “endoscopic,” “microsurgical,” and “acromegaly.” The specific search strategy for publications comparing endoscopic vs. microscopic transsphenoidal surgery is shown in Table 1. Furthermore, the reference lists of relevant studies and reviews were manually checked by two authors, to further identify other potential studies in the literature.

The search strategy for studies comparing endoscopic vs. microscopic transsphenoidal surgery.

Transsphenoidal surgery OR Neurologic surgical procedure OR Neuroendoscopy OR Microsurgery
AND
Pituitary OR Pituitary and surgery OR Pituitary adenomas OR Pituitary neoplasm
AND
(Non-functioning OR Functioning
OR
Acromegaly OR GH-secreting adenoma OR GH-producing adenoma OR Somatotroph tumor)
Inclusion and Exclusion Criteria

The study selection was in accordance with the following PICOS criteria: (I) population: strictly refers to the NFPA or FPA; (II) intervention: ETSS and MTSS; (III) comparison: the outcomes of procedure-related efficacy and safety; (IV) outcome measures: reports one or more of the including endpoints: gross-total resection (GTR), cerebrospinal fluid (CSF) leak, length of stay, visual improvement, hypothyroidism, meningitis, hematoma, operation time, diabetes insipidus, hypopituitarism, hypocortisolism, and mortality; and (V) the full-text of publications were written in English.

Our exclusion criteria are: (I) studies that lack details of postoperative efficacy or complications; (II) studies with an imbalance of clinical characteristics; (III) non-investigative studies like case report, case series, and single-armed studies; (III) conference proceedings, letters, animal trials, systematic reviews, and meta-analyses.

 Data Extraction

We assigned three authors to extract information of included studies, respectively. Two authors extracted all study design details from the full text of the included study, then the third author checked all extracted data. Discrepancies were resolved by consulting clinical experts. For each included study, the following details were extracted: study characteristics (first author, year of publication, country, sample size, study type), case characteristics (sex and age), and operation type. The following outcome items were also extracted: GTR, length of stay, diabetes insipidus, visual improvement, CSF leak, hypothyroidism, hypopituitarism, meningitis, hematoma, hypocortisolism, operation time, and mortality.

 Statistical Analysis

Comparisons of the postoperative complications after ETSS and MTSS were analyzed by the standard software STATA version 12.0. Heterogeneity among studies was assessed using Cochran's Q-test (p < 0.10) and the I2-value. In brief, when the I2 > 50%, we considered the heterogeneity to be high, and a random-effect model would be selected. Otherwise, a fixed-effect model was selected. As for continued variables, the length of stay and operation time were expressed as weighted mean differences (WMD) with 95% confidence intervals (CIs). For the binary variables, the odds ratios (ORs) or rate differences (RDs) with 95% CIs were applied for assessment. A p < 0.05 was considered to be statistically significantly different.

 Results Search Results

The initial search resulted in 3,412 English-language full-text studies from the electronic databases of PubMed, Cochrane Library, and EMBASE. Two-thousand-and-thirty-five of the articles were removed as a result of duplicates. One-thousand-one-hundred-and-sixty-six articles were deleted by screening the title and abstract based on the inclusion and exclusion criteria. The remaining 211 studies were used for full-text screening. Finally, 16 articles were selected for our final analysis, including 1003 patients who underwent ETSS, and 992 patients who underwent MTSS. Seven articles directly compared the two interventions for NFPA, Seven for FPA, while three articles compared the two groups for acromegaly. Figure 1 describes this in more detail.

Flowchart of the study selection process.

 Methodological Quality Assessment

In this study, the Newcastle-Ottawa Scale (NOS) was adopted to assess the quality of all observational studies with a score range between 0 ~ 9. Two authors (SFG and ZDW) evaluated the quality of the included literature independently. When differences arose in this process, the authors would discuss. All included articles were of high quality, and more details about the quality assessment of the included studies are shown in Table 2.

The literature quality assessment.

References Design Newcastle-Ottawa scale (NOS)
Selection Comparability Exposure Total scores
Sheehan et al. (13) Retrospective cohort study 2 2 2 6
Messerer et al. (14) Retrospective cohort study 4 1 2 7
Dallapiazza et al. (15) Retrospective cohort study 3 2 3 8
Karppinen et al. (16) Retrospective cohort study 3 1 2 6
Zaidi et al. (10) Retrospective cohort study 3 1 3 7
Pledger et al. (25) Retrospective cohort study 4 2 2 8
Little et al. (17) Prospective cohort study 4 2 3 9
Haens et al. (26) Retrospective cohort study 3 1 2 6
Choe et al. (18) Retrospective cohort study 4 2 2 8
Cheng et al. (19) Retrospective cohort study 3 2 2 7
Fathalla et al. (20) Retrospective cohort study 4 1 3 8
Gao et al. (21) Retrospective cohort study 3 1 3 7
Guo-Dong et al. (22) Retrospective cohort study 3 1 2 6
Starke et al. (23) Retrospective cohort study 3 2 2 7
Sarkar et al. (24) Retrospective cohort study 3 2 2 7
Castaño-Leon et al. (11) Prospective cohort study 4 2 2 8

NOS, Newcastle-Ottawa scale.

 Study Characteristics

In this study, a total of 16 studies (10, 11, 13–26) were included, hailing from Belgium, the USA, India, Finland, France, Korea, Spain, China, and Canada. We enrolled 1003 patients in the ETSS and 992 patients in the MTSS group. Patients with pituitary adenomas were divided into non-functional (775 patients), functional (687 patients), and acromegaly (291 patients) groups. In the NPFA patients, there were seven articles including 994 patients. Of those 994 NFPA participants, 484 belonged to the endoscopic group vs. 510 to the microscopic group. In FPA patients, there were Seven articles including 775 cases. Among those 775 FPA cases, 381 belonged to endoscopic treatment vs. 394 to microscopic treatment. As for the acromegaly group, there were Three articles including 291 participants. More information about the study characteristics is shown in Table 3.

Characteristics of publication year, country, study type, cases, and gender (Female/Male) in each group for included studies.

Author Country Years Type of study Sample size (n) Gender (F/M) Age (mean ± standard) NOS
Endoscopy Microscopy Endoscopy Microscopy Endoscopy Microscopy
Comparison of two intervention for treating non-functioning pituitary adenomas
Sheehan et al. USA 1999 Retrospective 26 44 8/18 13/31 59.2 ± 15.1 57.8 ± 14.9 6
Messerer et al. France 2011 Retrospective 82 82 35/47 31/51 57.0 (20–82) 56.5 (27–84) 7
Dallapiazza et al. USA 2014 Retrospective 56 43 19/24 29/27 56.7 ± 16.9 56.2 ± 12.8 8
Karppinen et al. Finland 2015 Retrospective 41 144 18/23 49/95 58.4 (17–83) 58.5 (16–86) 6
Zaidi et al. USA 2016 Retrospective 55 80 20/35 30/50 55.9 ± 13.8 59.1 ± 14.6 7
Pledger et al. USA 2015 Retrospective 47 35 24/23 18/17 52 (32.5–79.5) 54 (27–74) 8
Little et al. USA 2019 Prospective 177 82 73/104 30/52 58.6 ± 13.3 58.1 ± 14.0 9
Comparison of two intervention for treating functioning pituitary adenomas6
Haens et al. Belgium 2008 Retrospective 60 60 41/19 16/44 837 (10–70) 35 (10–68) 6
Choe et al. Korea 2008 Retrospective 12 11 7/5 9/2 47 ± 12 48 ± 10 8
Cheng et al. China 2011 Retrospective 68 59 37/31 39/20 37.82 (13–69) 33.8 (11–71) 7
Fathalla et al. Canada 2015 Retrospective 42 23 21/21 16/7 43.2 42.1 8
Gao et al. China 2016 Retrospective 60 45 34/26 26/19 44.6 (19–75) 48.8 (21–77) 7
Guo-dong et al. China 2016 Retrospective 100 147 41/59 94/53 43.4 ± 14.0 40.4 ± 14.2 6
Castaño-Leon et al. Spain 2020 Prospective 39 49 NA NA NA NA 8
Comparison of two intervention for treating acromegaly
Starke et al. USA 2013 Retrospective 72 41 40/32 21/20 49.2 ± 14.9 47.5 ± 14.2 7
Sarkar et al. India 2014 Retrospective 66 47 36/30 21/26 37.6 ± 10.8 38.7 ± 12.2 7
Fathalla et al. Canada 2015 Retrospective 42 23 21/21 16/7 43.2 42.1 8

NA, not available; F, female; M, male; NOS, Newcastle-Ottawa Scale.

 Outcomes Analyzed Items

The items analyzed in this study were: (1) the GTR, based on postoperative imaging confirming tumor absence; (2) the time of operation and length of stay for two surgery; and (3) postoperative complications (visual improvement, CSF leak, diabetes insipidus, hypothyroidism, hypocortisolism, meningitis, hematoma, hypopituitarism, and mortality). More information is shown in Table 4.

The postoperative outcomes of this meta-analysis.

Outcomes Studies numbers Groups size Overall effect Heterogeneity
Endoscopic Microscopic Effect estimate 95% CI P-value I2(%) P-value
Comparison of two interventions for treating non-functioning pituitary adenomas
Gross-total resection 5 250 383 OR, 1.655 1.131, 2.421 0.010 32.3% 0.206
CSF leak 7 472 510 RD, −0.010 −0.041, 0.020 0.506 0.0% 0.916
Diabetes insipidus 6 339 559 OR, 1.033 0.610, 1.751 0.903 32.5% 0.192
Visual improvement 2 69 93 OR, 3.636 0.634, 20.849 0.147 0.0% 0.366
Meningitis 4 355 388 RD, −0.004 −0.024, 0.015 0.653 0.0% 0.942
Hematoma 5 381 432 OR, 0.788 0.286, 2.169 0.645 35.5% 0.185
Hypopituitarism 4 171 244 OR, 0.753 0.433, 1.309 0.315 13.2% 0.327
Hypothyroidism 2 152 103 OR, 0.582 0.269, 1.259 0.169 0.0% 0.773
Hypocortisolism 3 246 182 OR, 0.640 0.142, 2.890 0.562 82.7% 0.003
Total mortality 2 259 164 RD, −0.001 −0.020, 0.019 0.958 0.0% 0.960
Length of Stay 3 288 205 WMD, 0.112 −0.791, 1.014 0.808 61.2% 0.076
Comparison of two interventions for treating functioning pituitary adenomas
Gross–total resection 5 229 244 OR, 2.033 1.335, 3.096 0.001 17.6% 0.302
CSF leak 6 342 345 OR, 1.054 0.535, 2.076 0.880 0.0% 0.445
Diabetes insipidus 6 341 237 RD, −0.136 −0.319, 0.047 0.145 96.7% 0.000
Visual improvement 3 71 54 OR, 2.461 1.109, 5.459 0.027 25.6% 0.261
Meningitis 4 232 263 OR, 0.195 0.041, 1.923 0.039 0.0% 0.998
Hematoma 2 112 158 RD, 0.015 −0.023, 0.053 0.440 0.0% 0.838
Hypopituitarism 5 282 285 OR, 0.675 0.299, 1.521 0.343 48.4% 0.101
Total mortality 2 120 105 RD, 0.000 −0.025, 0.025 1.000 0.0% 1.000
Length of Stay 3 228 251 WMD, −1.284 −3.656, 1.089 0.289 95% 0.000
Operation time 4 325 336 WMD, 4.022 −53.674, 61.719 0.891 99.0% 0.000
Comparison of two interventions for treating acromegaly
CSF leak 3 181 111 OR, 0.581 0.163, 2.079 0.404 0.0% 0.791
Diabetes insipidus 3 179 111 OR, 0.905 0.203, 4.029 0.896 68.4% 0.042
Hypopituitarism 2 108 70 OR, 1.214 0.531, 2.77 0.646 0.0% 0.368
Hypothyroidism 2 136 86 OR, 0.576 0.228, 1.457 0.244 0.0% 0.560
Hypocortisolism 2 132 87 OR, 0.703 0.111, 4.476 0.709 77.8% 0.034

CIs, confidence intervals; RD, rate difference; OR, odds ratio; CSF, Cerebrospinal fluid. Bold values means P < 0.05.

 Comparison of Two Interventions for Treating Non-functioning Pituitary Adenomas Gross-Total Resection (GTR)

We adopted meta-analytical techniques to assess the incidence of postoperative GTR. Reviewing the data of the included studies, five publications (250 endoscopic and 383 microscopic) reported on the postoperative GTR. We selected the fixed effects model because the heterogeneity was not significantly different (P = 0.206, I2 =32.3%). The ETSS group was related to a higher incidence of postoperative GTR in NFAP participants (OR = 1.655, 95% CI 1.131–2.421, P = 0.010, Figure 2).

Forest plot on gross-total resection with ETSS vs. MTSS for NFPA.

 Length of Stay

Three studies (288 endoscopic, 205 microscopic) reported data on length of stay. We found that the difference between the two surgeries was not statistically significant (WMD = 0.112, 95% CI −0.791 to 1.014, P = 0.808).

 Postoperative Complications

The pooled estimates of the overall proportions showed no significant difference in the incidence of visual improvement (OR = 3.636, P = 0.147), diabetes insipidus (OR = 1.033, P = 0.903, Figure 3), hypocortisolism (OR = 0.640, P = 0.562), hematoma (OR = 0.788, P = 0.645), CSF leak (RD = −0.01, P = 0.506, Figure 4), hypopituitarism (OR = 0.753, P = 0.315), meningitis (RD = −0.004, P = 0.653), hypothyroidism (OR = 0.582, P = 0.169), and mortality (RD = −0.001, P = 0.958) according to the data of seven studies.

Forest plot on diabetes insipidus with ETSS vs. MTSS for NFPA.

Forest plot on cerebrospinal fluid leak with ETSS vs. MTSS for NFPA.

 Comparison of Two Interventions for Treating Functioning Pituitary Adenomas Gross-Total Resection (GTR)

Five publications (229 endoscopic, 244 microscopic) reported on the postoperative GTR. A fixed-effects model was used to assess this, due to no significant heterogeneity (P = 0.302, I2 = 17.6%). The GTR rate was 73.8% in the endoscopic group and 62.3% in the microscopic group. The pooled evaluation of the overall proportions demonstrated that a significantly higher rate of GTR appeared in the ETSS group (OR = 2.033, 95% CI 1.335–3.096, P = 0.001, Figure 5).

Forest plot on gross-total resection with ETSS vs. MTSS for FPA.

 Time of Operation and Length of Stay

Three studies (228 endoscopic, 251 microscopic) reported data on length of stay. We found that the difference was not statistically significant between the two groups (WMD = −1.284, 95% CI −3.656 to 1.089, P = 0.289). Similarly, the results showed that there was no significant difference found in the operation time (WMD = 4.022, 95% CI −53.674 to 61.719, P = 0.891).

 Postoperative Complications

Four studies reported data on meningitis. No significant heterogeneity was found, then the fixed effects model was selected (P = 0.998, I2 = 0%). We found that endoscopic treatment was related to lower meningitis rates than in the microscopic group (OR = 0.195, 95% CI 0.041–1.923, P = 0.039, Figure 6). Furthermore, endoscopic treatment had a higher incidence of visual improvement (OR = 2.461, 95% CI 1.109–5.459, P = 0.027, Figure 7). However, according to the data of six studies, a significant difference was not found between the two groups for diabetes insipidus (RD = −0.136, P = 0.145), hypocortisolism (OR = 0.675, P = 0.343), hematoma (RD = 0.015, P = 0.440), CSF leak (OR = 1.054, P = 0.880), and mortality (RD = 0.000, P = 1.000).

Forest plot on meningitis with ETSS vs. MTSS for FPA.

Forest plot on visual improvement with ETSS vs. MTSS for FPA.

 Comparison of Two Interventions for Treating Acromegaly Postoperative Complications

The pooled estimates of the overall proportions showed that the incidence of CSF leak (OR = 0.581, P = 0.404), hypopituitarism (OR = 1.214, P = 0.646), diabetes insipidus (OR = 0.905, P = 0.896), hypothyroidism (OR = 0.576, P = 0.244), and hypocortisolism (OR = 0.703, P = 0.709) was not significantly different between the two groups based on the data of three studies.

 Discussion Summarizing the Objectives and Main Findings

The current common operations for pituitary adenomas are ETSS and MTSS. Although the merits and disadvantages of ETSS vs. MTSS for treating pituitary adenoma have been assessed previously, the comparisons of two interventions, specifically on NFPA and FPA, have never been comprehensive and systematically performed before. Previous meta-analyses do not include a purely comparative study to evaluate the efficacy and safety between the two interventions, resulting in their ability to provide certain evidence for intervention remaining controversial. Thus, we conducted this meta-analysis to explore whether there were any differences in the risk of postoperative complications between the two groups in cases with NFPA or FPA. This quantitative analysis included 1995 patients with pituitary adenoma assessed in 16 studies, and this pooled data showed that FPA or NFPA patients treated by ETSS, had a higher incidence rate of GTR.

 MTSS Had a Higher Rate of GTR in Patients With NFPA or FPA

In this meta-analysis, the pooled statistic revealed that the NFPA participants treated with endoscopes had a higher incidence of GTR (OR = 1.655, 95% CI 1.131–2.421, P = 0.010). Likewise, a meta-analysis conducted by Gao et al. (27) found that the higher incidence of GTR appeared to be in patients treated with ETSS rather than those treated by MTSS (P = 0.0001), consistent with the study conducted by Yu et al. (28) (P < 0.001) Similarly, we also revealed that the proportion of GTR was also relatively higher in FPA cases treated by ETSS compared to patients treated by MTSS (OR = 2.033, 95% CI 1.335–3.096, P = 0.001). Parasellar extension accounted for most resection outcomes, with a panoramic view where endoscopy provides a wider and superior route to parasellar and suprasellar compartments, contributing to the higher rates of GTR (29). In brief, the endoscope is particularly useful in obtaining a panoramic view of the surrounding structures through the use of angled endoscopes.

 ETSS Resulted in a Lower Incidence of Meningitis and a High Incidence of Visual Improvement

Beyond what is described above, the lower rates of meningitis in patients with FPA undergoing ETSS was shown by the pooled data (OR = 0.195, 95% CI 0.041–1.923, P = 0.039). The origin behind the effect might be from the superiorities of ETSS, such as a shorter operation time. Moreover, there was a higher percentage of patients with FPA treated with ETSS who gained visual improvement (OR = 2.461, 95% CI 1.109–5.459, P = 0.027). ETSS has been proven to be more capable of exploring sella turcica with a panoramic view, which increases the success incidence and fully eliminates compression on optic chiasma due to sellar region lesions. Concerning patients with acromegaly, ETSS and MTSS demonstrated no statistically significant difference in controlling postoperative complications, which might be caused by the shortage of data extracted from only three included studies. With an increase in highly-qualified studies related to surgical treatment of acromegaly reported in the future, results of significance may yet be revealed.

 ETSS Did Not Lead to the Higher Rates of Postoperative Complications Such as CSF Leak and Diabetes Insipidus

There was no significant difference in the CSF leak and diabetes insipidus between the two modalities, irrespective of being NFPA or FPA patients. Reconstructive procedures following resection should be acknowledged as an essential factor for the risk of a postoperative leak of CSF (30). Theoretically, reconstruction performed with the endoscope, offering wider visualization, enjoyed a higher success rate. This would reduce the incidence of CSF leakage for patients treated by MTSS to some extent. Whereas, in this study, the discrepant incidence of postoperative CSF leaks was of no statistical significance. The main cause for this might be that elevated exposure during ETSS would result in more aggressive surgical exploration, leading to an increased rate of postoperative CSF leaks. Besides that, a learning curve (31, 32) was expected owing to the fact that ETSS was an updated technique, while it was impossible to incorporate a surgeon's level of experience. Thus, although actual complications might be different between ETSS and MTSS, the differences may be neutralized by the above factors. Additionally, a non-significant correlation exists between the lower rates of diabetes insipidus and ETSS when compared to MTSS, despite ETSS acquiring a higher rate of GTR. We suspect that the tumor type might play a key role in this effect (29), whereas no stratified results were described for most included trials to help us conduct a subgroup analysis.

 Study Limitations

This study had some limitations; (I) a great many of the related comparative articles were excluded from this articles due to the fact that various pituitary adenomas subtypes were involved and where specific information about NFPA or FPA could not be obtained; (II) this study assessed all endpoints with different follow-ups between the two groups, which could cause a bias; (III) although this study used a rigorous search strategy to identify all relevant studies, a small number of studies might have been overlooked; and (IV) microadenomas are different than invasive, cavernous sinus extended macroadenoma, and we were unable to perform a subgroup analysis based on adenoma size and Hardy-Wilson classification, due to the limited data.

 Conclusion

Based on current evidence, NFPA patients treated by endoscopy were had higher rates of GTR; FPA patients treated by ETSS had a higher rate of visual improvement and GTR, as well as a lower rate of meningitis.

 Data Availability Statement

The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author/s.

 Author Contributions

SG and XL designed the study, acquired the data, drafted the article, and analyzed and interpreted the data. ZW and XK revised the article critically for important intellectual content together. All authors approved the version to be published.

 Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Endoscopic transsphenoidal pituitary surgery: evidence of an operative learning curve. Neurosurgery. (2010) 67:1205–12. 10.1227/NEU.0b013e3181ef25c520871457 Abbreviations MTSS

microscopic transsphenoidal pituitary surgery

 GTR

Gross-total resection

 NFPA

non-functioning Pituitary Adenomas

 FPA

Functioning Pituitary Adenomas

 ETSS

endoscopic transsphenoidal pituitary surgery

 Cis

confidence intervals

 WMD

weighted mean differences

 CSF

cerebrospinal fluid

 RDs

rate differences

 ORs

odds ratios

 PRISMA

Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

Funding. This work was supported by the Zhao Yichang Incubation Fund Nursing Research Project of Tianjin Medical University General Hospital, No. 303071902801 (Yan Yuan).