AUTHOR=Li Yunke , Wen Dingke , Cui Wenyao , Chen Yuqi , Zhang Fazhen , Yuan Maolin , Xiao Han , Li Hao , Ma Lu , Hu Xin , You Chao 

TITLE=The Prognostic Value of the Acute Phase Systemic Immune–Inflammation Index in Patients With Intracerebral Hemorrhage

JOURNAL=Frontiers in Neurology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.628557

DOI=10.3389/fneur.2021.628557

ISSN=1664-2295

ABSTRACT=Background and purpose
The systemic immune–inflammation index (SII) is a novel prognostic index in various diseases. We evaluated the predictive value of SII in patients with intracerebral hemorrhage (ICH).
Methods
Patients with primary spontaneous ICH were enrolled. SII =was constructed based on peripheral  platelet (P),  neutrophil (N) and lymphocyte (L) and defined as P*N/L.x absolute neutrophil count/ absolute lymphocyte count. In addition to admission testing, acute phase SII was collected to analyze the potential dynamic change. Poor outcome was defined as modified Rankin Scale more than 3 at 90 days.
Results
We included 291 patients; 98 (34%) achieved favorable functional outcomes. Day-1 SII was higher and was more related to poor outcome than was admission SII. Median time of day-1 SII was 29 hours from onset. Day-1 SII had an OR in outcome (mRS >3) 1.74 (95% CI = 1.03–3.00, p = 0.04). The binary cut off point of SII calculated using the area under the curve (AUC) method was 1700 x 109/L, AUC 0.699 (95% CI = 0.627–0.774) (sensitivity 53.3%, specificity 77.3%) (OR = 2.36, 95% CI = 1.09–5.26, p = 0.03). 
Conclusions
SII, especially day-1 SII, was highly associated with 90-day functional outcome in patients with ICH and could be used to predict outcomes.