AUTHOR=Cai Lingxin , Zeng Hanhai , Tan Xiaoxiao , Wu Xinyan , Qian Cong , Chen Gao 

TITLE=The Role of the Blood Neutrophil-to-Lymphocyte Ratio in Aneurysmal Subarachnoid Hemorrhage

JOURNAL=Frontiers in Neurology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.671098

DOI=10.3389/fneur.2021.671098

ISSN=1664-2295

ABSTRACT=Aneurysmal subarachnoid hemorrhage (aSAH) is an important type of stroke with the highest rates of mortality and disability. Recent evidence indicates that neuroinflammation plays a critical role in both early brain injury and delayed neural deterioration after aSAH, contributing to unfavorable outcomes. The neutrophil to lymphocyte ratio (NLR) is a peripheral biomarker that conveys information about the inflammatory burden in terms of both innate and adaptive immunity. This review summarizes some relevant studies that associate the NLR with aSAH to evaluate whether the NLR can predict outcomes and be used as an effective biomarker for clinical management. The underlying pathophysiology is highlighted to identify new potential targets for neuroprotection and to develop novel therapeutic strategies.