AUTHOR=You Hong-Hai , Chen Xiao-Yong , Chen Jin-Yuan , Bai Yue , Chen Fu-Xiang 

TITLE=The Relationship Between Peritumoral Brain Edema and the Expression of Vascular Endothelial Growth Factor in Vestibular Schwannoma

JOURNAL=Frontiers in Neurology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.691378

DOI=10.3389/fneur.2021.691378

ISSN=1664-2295

ABSTRACT=Objective To explore the potential mechanism of peritumoral brain edema (PTBE) formation in vestibular schwannoma (VS) by detecting intra-tumoral vascular endothelial growth factor (VEGF) expression.
Methods Between January 2018 and May 2021, 15 patients combined with PTBE and 25 patients without PTBE were included in the analysis. All patients enrolled in our study underwent surgery in our institution. Expression level of VEGF and microvessel density (MVD) between the two groups were analyzed. Edema index (EI) of each patient with PTBE was calculated.
Results In the PTBE group, the average of EI was 1.53±0.22. VEGF expression levels were significantly enhanced in the PTBE group compared with the non-PTBE group (P<0.001). The expression level of VEGF in the PTBE group and non-PTBE group was 1.14±0.21 and 0.52±0.09, respectively. Similarly, there were significantly different amounts of MVD in the two groups (P<0.001). The amount of MVD in the PTBE group and non-PTBE group was 11.33±1.59 and 6.28±1.77, respectively. Correlation analysis showed a highly significant positive correlation between VEGF and MVD (r=0.883, P<0.001), VEGF and EI (r=0.876, P<0.001).
Conclusion Our study confirmed the close relationship among VEGF expression, tumor angiogenesis, and formation of PTBE in VS patients. It may be possible to develop new effective therapies to attenuate PTBE in VS for alleviation of symptoms and reduction of postoperative complication.