AUTHOR=Schindler Kaspar A. , Rahimi Abbas TITLE=A Primer on Hyperdimensional Computing for iEEG Seizure Detection JOURNAL=Frontiers in Neurology VOLUME=Volume 12 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.701791 DOI=10.3389/fneur.2021.701791 ISSN=1664-2295 ABSTRACT=A central challenge in today’s care of epilepsy patients is that the disease dynamics are severely under-sampled in the currently typical setting with appointment-based clinical and electroencephalographic examinations. Implantable devices to monitor electrical brain signals and to detect epileptic seizures may significantly improve this situation and may inform personalized treatment on an unprecedented scale. These implantable devices should be optimized for energy-efficiency and compact design. Energy-efficiency will ease their maintenance by reducing the time of recharging, or by increasing the lifetime of their batteries. Biological nervous systems use an extremely small amount of energy for information processing. In recent years a number of methods, often collectively referred to as brain-inspired computing, have been developed to improve computation in non-biological hardware, too. Here we give an overview of one of these methods, which has in particular been inspired by the very size of brains’ circuits, and has been termed hyperdimensional computing. Using a tutorial style we set out to explain the key concepts of hyperdimensional computing including very high-dimensional binary vectors, the operations used to combine and manipulate these vectors and the crucial characteristics of the mathematical space they inhabit. We then demonstrate step-by-step how hyperdimensional computing can be used to detect epileptic seizures from intracranial EEG recordings with high energy-efficiency, high specificity and high sensitivity. We conclude by describing potential future clinical applications of hyperdimensional computing for the analysis of EEG and non-EEG digital biomarkers.