AUTHOR=Lin Changchun , Pan Hui , Qiao Yuan , Huang Peisheng , Su Jingjing , Liu Jianren 

TITLE=Fibrinogen Level Combined With Platelet Count for Predicting Hemorrhagic Transformation in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy

JOURNAL=Frontiers in Neurology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.716020

DOI=10.3389/fneur.2021.716020

ISSN=1664-2295

ABSTRACT=A serious complication of acute ischemic stroke (AIS) after mechanical thrombectomy (MT) is hemorrhagic transformation, which is potentially associated with clinical deterioration. This study examined predictors of HT following MT in AIS patients. Patients with AIS due to large artery occlusion in the anterior circulation, treated with MT and recanalization, were studied retrospectively. HT was evaluated by computed tomography (CT) 24 h after MT. Multivariate logistic regression models were used to determine the risk factors for HT. Receiver operating characteristic (ROC) curve analysis was performed to determine the predictive utility of risk factors for HT. We enrolled 135 patients: 49 in the HT group and 86 in the non-HT group. The two groups differed significantly in baseline fibrinogen levels (P=0.003) and platelet counts (P=0.006). Multivariate logistic regression analyses showed that lower fibrinogen levels (OR, 0.41; 95% CI, 0.23–0.72; P=0.002) and platelet counts (OR, 0.58; 95% CI, 0.33–0.99; P=0.048) were independently associated with a higher risk of HT. Together, the binary variates fibrinogen and platelets well predicted HT (area under the curve, 0.703; specificity, 77.9%; sensitivity, 55.1%). The combination of fibrinogen < 2.165 g/L and platelets < 171.5 × 109/L was the strongest predictor of HT (OR, 23.17; 95%CI, 5.75–126.80; P<0.0001). Lower baseline fibrinogen levels and platelet counts are risk factors for HT in AIS patients treated with MT and reperfusion. The combination of fibrinogen and platelets can predict the risk of HT after MT in these patients.