AUTHOR=LaGrange Daniela Dumitriu , Wanke Isabel , Machi Paolo , Bernava Gianmarco , Vargas Maria , Botta Daniele , Berberat Jatta , Muster Michel , Platon Alexandra , Poletti Pierre-Alexandre , Lövblad Karl-Olof 

TITLE=Multimodality Characterization of the Clot in Acute Stroke

JOURNAL=Frontiers in Neurology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.760148

DOI=10.3389/fneur.2021.760148

ISSN=1664-2295

ABSTRACT=Aim: Current treatment of occluded cerebral vessels can be done by a variety of endovascular techniques. Sometimes the clot respond in varying degrees to the treatment chosen. Ex vivo characterization of the clot occluding the arteries in acute ischemic stroke can help understand the underlying imaging features obtained in pre-treatment brain scans. For this reason, we explored the potential of microCT, when combined with electron microscopy, for clot characterization. Results were compared to the clinical CT findings.
Methods: 16 patients (9 males, 8 females, age range 34-90 years) who were referred to our institution for acute stroke, underwent dual-source CT.
Results: on clinical CT clots were seen as either iso or hyperdense. This was corroborated with micro-CT and electronmicroscopy can show the detailed composition.
Conclusion: MicroCT values can be used as an indicator for red blood cells rich composition of clots. Meaningful information regarding the clot composition and modalities of embedding along the stent retrievers can be obtained through a combination of microCT and electron microscopy.