AUTHOR=Iverson Grant L. , Greenberg Jonathan , Cook Nathan E. TITLE=Anxiety Is Associated With Diverse Physical and Cognitive Symptoms in Youth Presenting to a Multidisciplinary Concussion Clinic JOURNAL=Frontiers in Neurology VOLUME=Volume 12 - 2021 YEAR=2022 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.811462 DOI=10.3389/fneur.2021.811462 ISSN=1664-2295 ABSTRACT=Introduction: Pre-injury and post-injury anxiety are prevalent and important to consider in the medical management of concussions in youth. We examined the association between anxiety and other physical, cognitive, and emotional symptoms in injured adolescents and young adults undergoing an initial evaluation in a specialty concussion clinic. Methods: Participants were 158 adolescents and young adults presenting to a multidisciplinary concussion clinic for evaluation and treatment (54.4% girls and women; mean age=17.3 years; SD=2.9). Their median days post injury was 29 (interquartile range=14-49; range=7-349). They were divided into binary groups based on whether they had a pre-injury history of anxiety diagnosis or treatment and whether they were experiencing current anxiety in the week prior to the evaluation, and then compared on the Post-Concussion Symptom Scale. Results: Youth with a pre-injury history of anxiety reported greater post-concussion symptoms (Md total score=36.0, IQR=21.5-53.0) compared to youth with no pre-injury history of anxiety (Md total score=20.5, IQR=6.0-36.0; MW U=1,520.00 p=.001, r=0.26, small-medium effect size). They reported significantly worse headaches, nausea, balance difficulty, dizziness, vision problems, fatigue, concentration difficulty, irritability, nervousness, sadness, feeling more emotional, trouble falling asleep, and sleeping more than usual. Youth with high post-injury anxiety reported greater post-concussion symptoms (Md total score=55.0, IQR=33.0-62.5) compared to youth with low post-injury anxiety (Md total score=19.0, IQR=6.0-35.0; MW U=681.00, p<.001, r=0.49, large effect size). They reported significantly worse headaches, nausea, vomiting, dizziness, vision problems, fatigue, sensitivity to light, feeling mentally foggy, feeling slowed down, concentration difficulty, memory difficulty, irritability, sadness, feeling more emotional, drowsiness, trouble falling asleep, sleeping less than usual, and sleeping more than usual. Logistic regressions revealed that both pre-injury and post-injury anxiety were strong predictors of persistent post-concussion symptoms, while attention-deficit hyperactivity disorder and pre-injury migraines were not significant predictors. Discussion: Pre-injury and post-injury anxiety are important risk factors for greater post-concussion symptoms among adolescents and young adults. Assessment of anxiety is important for the prognosis and treatment plans of these individuals.