AUTHOR=Wang Meng , Chen Ni , Sun Bai-chao , Guo Chun-Bao , Zhang Shuang , Huang Ming-Jie , Zhou Ben-Gang , Wang Xiang-yu , Huang Zheng-Biao 

TITLE=Association between glaucoma and risk of stroke: A systematic review and meta-analysis

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.1034976

DOI=10.3389/fneur.2022.1034976

ISSN=1664-2295

ABSTRACT=Abstract
Background/objectives: Recently, several studies explored the association between glaucoma and the risk of stroke, but these results were inconsistent. Therefore, we conducted a meta-analysis to examine this possible association.
Methods: We conducted a systematic literature search of PubMed, Embase and Web of Science from inception until February 2022.Random-effects meta-analysis were conducted by generic inverse variance method. Sensitivity and subgroup analyses were performed. The review protocol has been registered with PROSPERO (CRD42022312797).
Results: Seven studies (involving 362267 participants) have been published from 2004 to 2017 included in the meta-analysis. These studies included four retrospective cohort studies, two cross-sectional studies and one case-control study. Meta-analysis of these data has shown that glaucoma was associated with an increased risk of stroke (OR=1.94, 95% CI=1.45-2.59). Most of the subgroup analyses demonstrated similar results. These findings were stable in sensitivity analyses.
Conclusions: we found that glaucoma was associated with increased risk of stroke. The result suggests that patients with glaucoma need to be assessed the risk of stroke to reduce the incidence of stroke. To better explore the nature of any association, prospective studies that consider of the stroke subtypes, sample size, district and other confounding factors are needed.