AUTHOR=Xiufu Zhang , Ruipeng Liang , Jun Zhou , Yonglong Li , Yulin Wang , Jian Zeng , Xianglin Chen , Lan Shen , Zuowen Zhang 

TITLE=Analysis of influencing factors of early neurological improvement after intravenous rt-PA thrombolysis in acute anterior circulation ischemic stroke

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.1037663

DOI=10.3389/fneur.2022.1037663

ISSN=1664-2295

ABSTRACT=It has been widely reported that Early neurological improvement (ENI) after rt-PA intravenous thrombolysis contributes to a good long-term prognosis in patients experiencing acute ischemic stroke (AIS). However, which clinical factors influence after intravenous administration of recombinant tissue-type plasminogen activator (IV-rt PA) in AIS patients ENI is still unclear. This study aimed to investigate the clinical factors affecting ENI in patients with acute anterior circulation ischemic stroke after intravenous thrombolysis with rt-PA. This retrospective study shows that in patients with acute precirculation ischemic stroke who receive rt-PA intravenous thrombolysis, diabetes mellitus (hyperglycemic levels) is a clinical risk factor for ENI after thrombolysis.