AUTHOR=Liu Yu-yang , Yao Ren-qi , Long Li-yan , Liu Yu-xiao , Tao Bing-Yan , Liu Hong-yu , Liu Jia-lin , Li Ze , Chen Ling , Yao Yong-ming 

TITLE=Worldwide productivity and research trend of publications concerning glioma-associated macrophage/microglia: A bibliometric study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.1047162

DOI=10.3389/fneur.2022.1047162

ISSN=1664-2295

ABSTRACT=Glioma associated macrophage/microglia (GAM) represents key player in shaping unique glioma ecosystem to facilitate tumor progression and therapeutic resistance. Numerous studies have been published in GAM, whereas no relevant bibliometric study has been performed up to now. Our bibliometric study aimed to comprehensively summarize and analyze the global scientific output, research hotspots and trendy topics of publications on GAM over time. Data of publications on GAM were collected using the Web of Science (WoS). The search date was January 16, 2022, and the publications were collected from 2002 to 2021. Totally, 1224 articles and reviews were incorporated and analyzed in the current study. It showed that the annual publications concerning GAM kept increasing over the past 20 years. The USA had the largest number of publications and total citations. Holland EC, Kettenmann H and Gutmann DH were the top three authors in terms of citation frequency. Neuro-Oncology represented the most influential journal in GAM studies, with the highest H-index, total citations and publication numbers. The paper published by Hambardzumyan D in 2016 had the highest local citations. Additionally, the analysis of keywords implied that “prognosis”, “tumor microenvironment”, and “immunotherapy” might become research hotspots. Furthermore, trendy topics in GAM studies suggested that “immune infiltration”, “immune microenvironment”, “bioinformatics”, “prognosis” and “immunotherapy” deserved additional attention. In conclusion, this bibliometric study comprehensively analyzed publication trend of GAM studies for the past 20 years, in which the research hotspots and trendy topics were also uncovered. This information offered scholars critical references for conducting in-depth studies on GAM in the future.