AUTHOR=Liu Songyang , Liu Shen , Li Shuming , Liang Boran , Han Xiao , Liang Yonghui , Wei Xing 

TITLE=Nerves within bone and their application in tissue engineering of bone regeneration

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.1085560

DOI=10.3389/fneur.2022.1085560

ISSN=1664-2295

ABSTRACT=Nerves within bone plays an irreplaceable role in promoting bone regeneration. Crosstalk between nerve system and bone has arose attention of researchers in the field of basic medicine, clinical medicine and biomaterials science. Success bone regeneration relies on the appropriate participation of neural system components including nerve fibers, signaling molecules and neural-related cells,. Furthermore, more about the mechanisms through which nerves took part in bone regeneration and how these mechanisms could be integrated into tissue engineering scaffolds were under exploration. In the present review, we aimed to systematically elaborate the structural and functional interrelationship between nerve system and bone. In particular, peripheral nerves interact with bone through innervated axons, multiple neurotrophins and bone resident cells. Also, we aimed to summarize researches which took advantage of the neuro-osteogenic network to design tissue engineering scaffolds for bone repair.