AUTHOR=Li Dongshi , Huang Zhixin , Dai Yingyi , Guo Linling , Lin Songbin , Liu Xintong 

TITLE=Bioinformatic identification of potential biomarkers and therapeutic targets in carotid atherosclerosis and vascular dementia

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.1091453

DOI=10.3389/fneur.2022.1091453

ISSN=1664-2295

ABSTRACT=Background: Dementia due to vascular disease is the second most common cause of the disease. The prevalence of vascular dementia (VaD) has increased over the last decade. However, there are no licensed treatments for this disease. Carotid atherosclerosis (CAS) is highly prevalent and a main cause of ischemic stroke and VaD. We studied co-expressed genes to understand relationships between CAS and VaD and further reveal potential biomarkers and therapeutic targets of CAS and VaD.
Result：A total of 60 upregulated DEGs and 159 downregulated DEGs were identified. Among them, top 7 hub genes with a high degree of connectivity were picked out. Overexpression of these hub genes was associated with CAS and VaD. Finally, top 7 hub genes coupled with corresponding predicted miRNAs. The hsa-miR-567and hsa-miR-4652-5p may be significantly associated with CAS and VaD.