AUTHOR=Huang Shuangfeng , Huang Qianqian , Zhou Zhongbao , Zhang Junliang , Zhan Yan , Liang Zhigang 

TITLE=The Efficacy of V. odorata Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.730311

DOI=10.3389/fneur.2022.730311

ISSN=1664-2295

ABSTRACT=Aim: This systematic review and meta-analysis was performed to assess the effect of Viola odorata (V.odorata) extract in the treatment of insomnia.
Methods: PubMed, EMBASE, and Cochrane Library databases, as well as references of related articles, were searched. Finally, four articles with five clinical trials including 224 patients were included in the analysis. 
Results: The obtained results indicated a greater improvement in total PSQI scores (MD, -4.67; P=0.0002), subjective sleep quality score (MD, -0.91; P=0.003), sleep duration score (MD, -0.77; P<0.00001), and ISI score (MD, -6.30; P=0.009) in the Viola extract group compared with the placebo group. However, the Viola extract group did not significantly differ in sleep latency (MD, -0.85; P=0.08), habitual sleep efficiency (MD, -0.61; P=0.21), sleep disturbances (MD, -0.36; P=0.11), and daytime dysfunction (MD, -0.94; P=0.12) from the placebo group.
Conclusions: Viola extract supplement led to a greater improvement in total PSQI scores, subjective sleep quality score, sleep duration score, and ISI score compared with the placebo group of patients with chronic insomnia.