AUTHOR=Pimentel Gabriela Almeida , Guimarães Thiago Gonçalves , Silva Guilherme Diogo , Scaff Milberto 

TITLE=Case Report: Neurodegenerative Diseases After Severe Acute Respiratory Syndrome Coronavirus 2 Infection, a Report of Three Cases: Creutzfeldt–Jakob Disease, Rapidly Progressive Alzheimer's Disease, and Frontotemporal Dementia

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.731369

DOI=10.3389/fneur.2022.731369

ISSN=1664-2295

ABSTRACT=The relationship of SARS-CoV-2 and neurodegenerative diseases is yet to be fully clarified. Fast worsening and even new onset cases of those disorders have been reported in association with COVID-19. In this series, we describe three cases of neurodegenerative diseases in patients with SARS-CoV-2: a case of Creutzfeldt-Jakob disease during COVID-19 acute phase, to our knowledge the second one described in the literature; a rapidly progressive Alzheimer´s Disease; and a patient with frontotemporal dementia and a quick decline of both cognitive and behavioral domains. This report aims at drawing neurologist´s attention to the possibility of an association between SARS-CoV-2 and a higher probability of developing or accelerating neurodegenerative chronic neurologic conditions, and reinforce the need for a close cognitive follow-up after the infection is resolved.