AUTHOR=Wan Yan , Guo Hongxiu , Shen Jing , Chen Shaoli , Li Man , Xia Yuanpeng , Zhang Lei , Sun Zhou , Chen Xiaolu , Chang Jiang , Wang David , He Quanwei , Hu Bo 

TITLE=Association Between Preonset Anti-hypertensive Treatment and Intracerebral Hemorrhage Mortality: A Cohort Study From CHEERY

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.794080

DOI=10.3389/fneur.2022.794080

ISSN=1664-2295

ABSTRACT=Introduction: Hypertension is the most prevalent risk factor for intracerebral hemorrhage (ICH). In this study we investigated whether preonset antihypertension could affect the outcomes of ICH. 
Methods: This was a retrospective cohort study. A total of 3460 consecutive patients with acute first-ever ICH from 31 recruitment sites were enrolled into the Chinese cerebral hemorrhage: mechanism and intervention (CHERRY) study from December 1, 2018 to November 30, 2020, and 2140 (61.8%) with hypertension history were entered into the analysis. 
Results: Only 586 (27.4%) with hypertension history currently received anti-hypertensive therapy, and which was associated with lower SBP and DBP on admission (SBP, P=0.008; DBP, P=0.017), less hematoma volume (9.8% vs. 11%, P=0.006) and lower all-cause mortality at 3 months (15.3% vs. 19.8%, OR=0.728, P=0.016). In multivariable analysis adjusting for age, gender, residence, ischemic stroke history, admission SBP and DBP, current use of anti-hypertension was significantly associated with lower adjusted HRs for all-cause mortality at discharge (adjusted HR, 0.497, P=0.012), 30 days (adjusted HR, 0.712, P=0.015) and 90 days (adjusted HR, 0.766, P=0.030). However, after adjusting the variable of hematoma volume, the mortality between two groups was not significantly different.
Conclusions: Preonset antihypertension was associated with lower mortality of ICH, which was somewhat depended on hematoma volume.