AUTHOR=Qiao Xinxin , Duan Jinfeng , Zhang Nan , Duan Yang , Wang Xinrui , Pei Yusong , Xu Zhihua , Yang Benqiang , Qi Miao , Li Jinze 

TITLE=Risk Factors of Impaired Perfusion in Patients With Symptomatic Internal Carotid Artery Steno-Occlusive Disease

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.801413

DOI=10.3389/fneur.2022.801413

ISSN=1664-2295

ABSTRACT=.Objective: To quantitatively evaluate the impaired perfusion status of patients with symptomatic internal carotid artery (ICA) steno-occlusive disease and to explore the risk factors of impaired perfusion on CTP.

Methods: The clinical and imaging data from 120 patients with ICA steno-occlusive disease were retrospectively analyzed. They were categorized as groups without impaired perfusion (n = 54 [45.0%]) or with impaired perfusion (n = 66 [55.0%]). Symmetrical bilateral internal watershed areas were selected as the regions of interest (ROIs). The risk factors of impaired perfusion were analyzed statistically.

Results: CBF/CBV value of 7.55/min was the best cut-off value for predicting symptomatic patients. Univariate analysis found that there were significant differences in diabetes, admission systolic blood pressures (SBP), diastolic blood pressures (DBP), mean arterial pressures (MAP), types of the circle of Willis and clinical features between different groups (patients with or without impaired perfusion) (P<0.05); Multiple logistic regression analysis found that admission MAP (odds ratio [OR]=0.915, 95% confidential interval [CI]=0.875-0.957, P =0.000), type Ⅳ (type I vs type Ⅳ: OR=5.999, 95% CI=1.743-20.643, P=0.004) were independently associated with impaired perfusion in the internal watershed areas. 

Conclusion: Admission MAP and type of circle of Willis are independent risk factors associated with the impaired perfusion in patients with ICA steno-occlusive disease.