AUTHOR=Eren Fettah , Ozguncu Cihat , Ozturk Serefnur 

TITLE=Short-Term Prognostic Predictive Evaluation in Female Patients With Ischemic Stroke: A Retrospective Cross-Sectional Study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.812647

DOI=10.3389/fneur.2022.812647

ISSN=1664-2295

ABSTRACT=Introduction and aim: Stroke is a disease with high mortality and morbidity. Although studies are generally performed on all stroke patients, it is known that gender has an effect on etiology and prognosis. In this study, it was aimed to determine the importance of clinical stroke scales and laboratory markers in female patients with ischemic stroke of anterior circulation.
Materials and Methods: The study was planned as a retrospective and cross-sectional study. SEDAN score, NIH stroke scale (NIHSS), Modified Rankin Scale (mRS), Glasgow Coma Scale (GCS) and THRIVE score applied to the patients at the time of admission were recorded. Admission blood glucose, hemoglobin, leukocyte, urea, albumin, and blood lipid levels were evaluated. The relationship of all these parameters with in-hospital prognosis, mortality, and disability during discharge was examined. The relationship between groups and data was analyzed using the SPSS package program after normality analysis.
Results: There were 611 female patients in the study with a mean age of 68.97 ± 14.61 years and 683 male stroke patients with a mean age of 64.62 ± 13.48 years. Hospitalization time, length of stay in the intensive care unit, ventilation need rate, mortality, and dependency rate were higher in female patients (p = 0.001). The NIHSS, SEDAN, and THRIVE scores were higher in female patients who had in-hospital mortality, had a poor prognosis and were discharged as a dependent (p = 0.001). GCS was lower in this patient groups (p = 0.001). Blood glucose, creatinine, leukocytes, urea, and CRP levels were higher; albümin and hemoglobin levels were lower in female patients who had a mortal course (p = 0.006; 0.001, 0.001, 0.001, 0.001, 0.026; respectively). In female patients who were dependent at discharge; blood urea, glucose, CRP level was higher and albumin level was lower (p  = 0.001, 0.017, 0.002, 0.001; respectively).
Conclusion: Our study showed that the short–term prognosis is worse in female patients who had an ischemic stroke of anterior circulation. It also revealed some clinical and laboratory parameters that could predict this situation. More intensive monitoring may be needed to improve the prognosis in female patients.