AUTHOR=Cai Zongyan , Li Shuo , Yu Tianci , Deng Jiahui , Li Xinran , Jin Jiaxin 

TITLE=Non-Coding RNA Regulatory Network in Ischemic Stroke

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.820858

DOI=10.3389/fneur.2022.820858

ISSN=1664-2295

ABSTRACT=Stroke is a worldwide public health problem, which has caused a substantial economic burden to families and society. There is still a lack of timely, effective diagnosis and treatment methods because of ischemic stroke's acute onset and narrow therapeutic time window. ncRNAs, which widely exist in the human body, do not encode proteins but mediate various cellular processes as functional regulatory molecules from the RNA level. Each ncRNA node in organisms is not isolated but constitutes a complex regulatory network, regulating multiple molecular targets and triggering specific physiological or pathological reactions, leading to different outcomes. Abundant studies have proclaimed the impact of ncRNAs in ischemic stroke, which may enlighten new inspirations for diagnosing and treating ischemic stroke. This paper outlines the current understanding of the ncRNA regulatory network and reviews the recent evidence for the contribution of ncRNAs in the experimental ischemic stroke model