AUTHOR=Yan Kai , Shi Wen-Qing , Su Ting , Liao Xu-Lin , Wu Shi-Nan , Li Qiu-Yu , Yu Jing , Shu Hui-Ye , Zhang Li-Juan , Pan Yi-Cong , Shao Yi 

TITLE=Brain Activity Changes in Slow 5 and Slow 4 Frequencies in Patients With Optic Neuritis: A Resting State Functional MRI Study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.823919

DOI=10.3389/fneur.2022.823919

ISSN=1664-2295

ABSTRACT=Objective: We used the amplitude of low-frequency fluctuation (ALFF) method to investigate spontaneous brain activity in patients with optic neuritis (ON) in specific frequency bands.

Data and methods: A sample of 21 patients with ON (13 female and 8 male) and 21 healthy controls (HCs) underwent functional magnetic resonance imaging (fMRI) scans in the resting state. We analyzed the ALFF values at different frequencies (slow-4 band: 0.027–0.073 Hz; slow-5 band: 0.01–0.027 Hz) in ON patients and HCs.
Results: In the slow-4 frequency range, compared with HCs, ON patients had apparently lower ALFF in the c discuss insula and the whack precuneus. In the slow-5 frequency range, ON patients showed significantly increased ALFF in the left parietal inferior and the left postcentral.
Conclusion: Our results suggest that ON may be involved in abnormal brain function and can provide a basis for clinical research.