AUTHOR=Chen Jiarui , Liang Tuo , Cen Jiemei , Jiang Jie , Chen Tianyou , Li Hao , Liu Chong , Chen Jing , Zhan Xinli TITLE=Extracranial Vertebral Artery-Internal Jugular Vein-Spinal Vein Fistula in Neurofibromatosis Type I: Case Report and Literature Review JOURNAL=Frontiers in Neurology VOLUME=Volume 13 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.855924 DOI=10.3389/fneur.2022.855924 ISSN=1664-2295 ABSTRACT=Background: Cervical arteriovenous fistula (AVF) in neurofibromatosis type I(NF-1) is uncommon, and it brings challenges and difficulty in the treatment. Case presentation: A 39-year-old woman was diagnosed with NF-1-associated spontaneous vertebral artery-internal jugular vein-spinal vein fistula. The fistula was placed by coil embolization. Postoperative examination showed that the fistula closure was satisfied, and the patient's abnormal clinical manifestation disappeared without any complications after 24 months of interventional embolization. As per the literature, interventional embolization is the main treatment method nowadays, and it has the distinguishing features of less trauma, quick recovery, and a good prognosis. Conclusion: NF-1 associated with spontaneous arteriovenous fistula is rare in clinical practice, which carries significant challenges in treatment, and this could be effectively treated using endovascular embolism. Endovascular embolism could be the potential choice of treatment in NF-1 associated with AVF.