AUTHOR=Li Chen , Zhou Ji , Zhang Yi-Qun , Lv Jin , Zhang Ying-Ying , Qiu Han-Cheng , Liu Ao-Fei , Jiang Wei-Jian TITLE=The Jrecan Device: Preclinical Data of a Novel Thrombectomy Device in Acute Thromboembolism Model of Beagle Dogs JOURNAL=Frontiers in Neurology VOLUME=Volume 13 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.858670 DOI=10.3389/fneur.2022.858670 ISSN=1664-2295 ABSTRACT=Objective This study is to investigate the safety and efficiency of Jrecan® flow restoration system, a novel thrombectomy device, in an arterial thromboembolic occlusion model of beagle dogs. Methods A total of 12 acute thromboembolism Beagle dogs were randomized to receive mechanical thrombectomy with either Jrecan® flow restoration device or TrevoTM PROVUE Device (2:1). The recanalization rate and vessel ijuries were evaluated through DSA and microscopic examination. Result The 100% recanalization rate (mTICI 2b/3) were achieved in both groups. Endothelial and subendothelial injuries occurred in all target vessels. Focal disruption of internal elastic lamina was observed in 4 cases. The mean vessel injury score of the Jrecan® group was 1.16 ± 0.48, significantly lower than that of the TrevoTM group (1.54 ± 0.8) (P<0.001). Conclusion The Jrecan® and TrevoTM device demonstrated equally high recanalization rate in acute thromboembolism Beagle dogs. However, histological findings revealed that the Jrecan® stent seemed to be safer than the TrevoTM device during clot retrieval, which might be related to the more appropriate radial force provided by the Jrecan® stent resulted from its wider cell design.