AUTHOR=Yang Yuyuan , Wang Meng , Xu Lulu , Zhong Meixiang , Wang Yajuan , Luan Moxin , Li Xingao , Zheng Xueping 

TITLE=Cerebellar and/or Brainstem Lesions Indicate Poor Prognosis in Multiple Sclerosis: A Systematic Review

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.874388

DOI=10.3389/fneur.2022.874388

ISSN=1664-2295

ABSTRACT=Multiple sclerosis is a serious neurological disease that affects millions of people worldwide. 13 Cerebellar and brainstem symptoms are common in the course of multiple sclerosis, but their 14 prognostic value is unclear. This systematic review aimed to determine the relationship between the 15 location of lesions in the cerebellum and/or brainstem and the prognosis in multiple sclerosis. In this 16 systematic review, we searched and comprehensively read articles related to this research topic in 17 Chinese and English electronic databases (PubMed, Embase, Cochrane Library, CNKI, and CBM) 18 using search terms “multiple sclerosis,” “cerebellum,” “brainstem,” “prognosis,” and others. 19 Cerebellar and brainstem clinically isolated syndromes and clinically definite multiple sclerosis were 20 important predictors of transformation (hazard ratio, 2.58; 95% confidence interval, 1.58–4.22). 21 Cerebellar and/or brainstem lesions indicate a poor overall prognosis in multiple sclerosis, but 22 because of inconsistency, more clinical data are needed.