AUTHOR=Dieu Dao Ying Rachel , Dunlop Eleanor , Daly Alison , Lucas Robyn M. , Probst Yasmine , Black Lucinda J. 

TITLE=Total Dairy Consumption Is Not Associated With Likelihood of a First Clinical Diagnosis of Central Nervous System Demyelination

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.888559

DOI=10.3389/fneur.2022.888559

ISSN=1664-2295

ABSTRACT=Background: The evidence associating consumption of dairy products and risk of MS is contradictory and inconclusive.
Objective: To test associations between dairy consumption and the likelihood of a first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to MS.
Methods: We used data from the 2003–2006 Ausimmune Study, a population-based Australian, multicentre, matched case-control study (272 cases, 519 controls). Total dairy consumption (servings/day) was calculated by summing consumption of milk, cheese and yoghurt. Covariate-adjusted treatment effects using augmented inverse probability weighting was used to test for associations with FCD. We conducted sensitivity analyses in the subset of participants who had had a classic first demyelinating event (FDE), defined as a single, first episode of symptoms suggestive of CNS demyelination.
Results: There were no statistically significant associations between total dairy consumption (per one serving/day) and FCD (adjusted OR 1.00; 95% CI 0.93, 1.07; p=0.979). However, yoghurt consumption (consumer vs. non-consumer) was associated with an 11% decreased likelihood of FDE (adjusted OR 0.89; 95% CI 0.89, 0.79; p=0.046).
Conclusion: While total dairy consumption was not associated with FCD in this Australian case-control study, yoghurt consumption was associated with reduced likelihood of FDE.