AUTHOR=Liu Yingying , Ma Xiaomeng , Ma Lili , Su Zhumin , Li Donghong , Chen Xiaohong 

TITLE=Elevated ApoB/ApoA-I ratio is associated with acute anti-N-Methyl-D-aspartate receptor encephalitis, but not disease outcomes

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.896656

DOI=10.3389/fneur.2022.896656

ISSN=1664-2295

ABSTRACT=Objective: The purpose of the present study is to clarify the relationship between the apolipoprotein B100/apolipoprotein A-I (ApoB/ApoA-I) ratio and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis.
Methods: A total of 71 patients with anti-NMDAR encephalitis were included in this study, and their ApoB/ApoA-I ratio in baseline and follow-up were retrospectively analyzed.
Results: ApoB/ApoA-I ratio was closely correlated with baseline modified Rankin scale (mRS) score>3 in anti-NMDAR encephalitis patients. Subgroup analysis showed obvious differences between the high and low ApoB/ApoA-I ratio groups.
The ApoB/ApoA-I ratio was positively correlated with intensive care unit (ICU) treatment, length of hospital stay, baseline mRS score, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). The ratios of the high and low ApoB/ApoA-I ratio groups both improved in the follow-up.
Conclusion: The increased ApoB/ApoA-I ratio is associated with acute anti-NMDAR encephalitis, but not disease outcomes. Serum ApoB/ApoA-I ratio was related to inflammation and immunity in peripheral blood. The findings might provide a new idea for the further exploration in the pathogenesis and treatment of anti-NMDAR encephalitis.