AUTHOR=Schirò Giuseppe , Iacono Salvatore , Ragonese Paolo , Aridon Paolo , Salemi Giuseppe , Balistreri Carmela Rita 

TITLE=A Brief Overview on BDNF-Trk Pathway in the Nervous System: A Potential Biomarker or Possible Target in Treatment of Multiple Sclerosis?

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.917527

DOI=10.3389/fneur.2022.917527

ISSN=1664-2295

ABSTRACT=The growing incidence of neurodegenerative disorders in our populations is leading the research to identify potential biomarkers and targets for facilitating their early management and treatments. Biomarkers represent the crucial indicators of both physiological and pathological processes. Specific changes in molecular and cellular mechanisms of physiological processes traduce in biochemical alterations at systemic level, that can give us comprehensive information regarding the nature of any disease. In addition, any disease biomarker should be specific and reliable, able to consent of distinguishing the physiological condition of a tissue, organ, or system from disease, and be diverse among the various diseases, or subgroups or phenotypes of them. Accordingly, biomarkers can predict chances for diseases, facilitate their early diagnosis, and setting guidelines for the development of new treatments to treat diseases and for the disease-making process. Here, we focus our attention on Brain neurotrophic factor (BDNF)- Tropomyosin receptor kinase (Trk) pathway, describing its numerous roles in the maintenance of Central Nervous System (CNS) health as well as its implication in the pathogenesis of multiple sclerosis (MS). In addition, we evidence its features as potential biomarker and therapeutic target.