AUTHOR=Yalikun Ainizier , Yushan Maimaiaili , Hamiti Yimurang , Lu Cheng , Yusufu Aihemaitijiang TITLE=Intraneural or extraneural ganglion cysts as a cause of cubital tunnel syndrome: A retrospective observational study JOURNAL=Frontiers in Neurology VOLUME=Volume 13 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.921811 DOI=10.3389/fneur.2022.921811 ISSN=1664-2295 ABSTRACT=Abstract Purpose Cubital tunnel syndrome caused by ganglion cysts has rarely been reported. The purpose of this study was to evaluate surgical treatment outcomes of a patient diagnosed with cubital tunnel syndrome caused by intraneural or extraneural cysts and to summarize our experience. Method Thirty-four patients were evaluated retrospectively from January 2011 to January 2020 with follow-up of more than 24 months. Preoperative data including demographic data, clinical symptoms, physical examination findings, and laboratory tests were all recorded and pre-operative and post-operative data were compared. The function was evaluated by the modified Bishop scoring system and McGowan grade at the last follow-up. Results Improvement of Interosseous muscle strength, Visual Analogue Scale (VAS), 2-point discrimination (2-PD), electromyogram(EMG) result, Wartenberg sign, claw hand, and weakness could be clearly observed in all patients. Extraneural cysts were completely removed and the pedicles of the cysts were ligated. Intraneural cysts were incised and drained, and part of its cyst wall was removed using a microsurgical technique. All patients underwent Anterior Subcutaneous Transposition(AST); At the last follow-up, McGowan's (0-IIa) grade increased from 7 patients (20.6%) preoperatively to 27 patients (79.4%); the excellent and good rate according to modified Bishop scoring system was 82.4% (28 patients), and all patients had no symptoms of recurrence after surgery. Conclusion The treatment of cubital tunnel syndrome caused by intraneural or extraneural cysts has achieved good long-term results through extraneural cyst resection or intraneural cyst incision and drainage combined with subcutaneous transposition. Early diagnosis and surgical treatment are essential for the patient's postoperative recovery.