AUTHOR=Zhang Dandan , Chen Siyuan , Xu Shoucheng , Wu Jing , Zhuang Yuansu , Cao Wei , Chen Xiaopeng , Li Xuezhong 

TITLE=The clinical correlation between Alzheimer's disease and epilepsy

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.922535

DOI=10.3389/fneur.2022.922535

ISSN=1664-2295

ABSTRACT=Previous study has suggested that epilepsy is a common complication of late dementia, and is a result of neurodegenerative diseases. Recent studies have found that seizures can occur in the early stages of Alzheimer's disease (AD). Furthermore, individuals with a history of epilepsy may have a higher risk of developing AD. Long-term repeated epilepsy, such as temporal lobe epilepsy, can cause cognitive impairment, which can lead to AD, and is often the cause of neurodegenerative lesions. Therefore, AD and epilepsy are inter-associated diseases, and they may have a common pathogenesis. Many studies have evaluated the shared pathogenesis and clinical relevance of AD and epilepsy. In this review, we discuss the clinical links between AD and epilepsy, including incidence, clinical features, and electroencephalogram (EEG) abnormalities. We summarized clinical studies between the two disorders in recent years. We also review new antiepileptic drugs as treatments for AD.