AUTHOR=Lin Hong-yu , Wei Qing-qing , Huang Jian-yi , Pan Xing-hua , Liang Ning-chao , Huang Cai-xia , Long Teng , Gao Wen , Shi Sheng-liang 

TITLE=Relationship Between Mortality and Seizures After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.922677

DOI=10.3389/fneur.2022.922677

ISSN=1664-2295

ABSTRACT=Background：The relationship between mortality and seizures after intracerebral hemorrhage (ICH) has not be understood until now. A meta-analysis was performed to assess the effect of post-ICH seizures on mortality among ICH patients. 
Methods: PubMed and Embase were searched from the establishment of the databases to December 2021 to identify literature that evaluated the relationship between post-ICH seizures and mortality in ICH. Crude odds ratios and adjusted odds ratios with a 95% confidence interval (CI) were pooled using a random-effects model. 
Results: Thirteen studies involving 245,908 participants were included for analysis eventually. The pooled estimate suggested that post-ICH seizures were not associated with a significant increased mortality in patients with ICH (crude adds ratios 1.35, 95% CI: 0.91–2.00; adjusted adds ratios 1.22, 95% CI: 0.78–1.88). However, the relationship was not consistent in subgroup analysis or robust in sensitivity analysis.
Conclusions: This meta-analysis proved that post-ICH seizures were not associated with a significant increased mortality in patients with ICH. However, this result could be influenced by confounding factors and so more high quality research is needed.