AUTHOR=Li Ze-Yang , Ma Teng , Yu Ying , Hu Bo , Han Yu , Xie Hao , Ni Min-Hua , Chen Zhu-Hong , Zhang Yang-Ming , Huang Yu-Xiang , Li Wen-Hua , Wang Wen , Yan Lin-Feng , Cui Guang-Bin 

TITLE=Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.923310

DOI=10.3389/fneur.2022.923310

ISSN=1664-2295

ABSTRACT=Abstract
Objective: Neuroimaging meta-analysis identified abnormal neural activity alterations in patients with type 2 diabetes mellitus (T2DM), but there was no consistency or heterogeneity analysis between different brain imaging processing strategies. The aim of this meta-analysis was to determine the consistent changes of regional brain function in T2DM from the indicators obtained by different post-processing methods.

Methods: Since the indicators obtained from varied post-processing methods reflect different neurophysiological and pathological characteristics, we further conducted a coordinated-based meta-analysis (CBMA) of the two categories of neuroimaging literature, which were grouped according to similar data processing methods. One group included regional homogeneity (ReHo), independent component analysis (ICA) and degree centrality (DC) studies, while another group summarized the literature on amplitude of low frequency fluctuation (ALFF) and cerebral blood flow (CBF).

Results: The final meta-analysis included 23 eligible trials with 27 data. Compared with the healthy control group, when neuroimaging studies were combined with ReHo, ICA and DC measurements, the brain activity of the right rolandic operculum, right supramarginal gyrus and right postcentral gyrus in T2DM patients decreased significantly. When neuroimaging studies were combined with ALFF and CBF measurements, there was no clear evidence of differences in the brain function between T2DM and HC.

Conclusion: T2DM patients have a series of spontaneous abnormal brain activities, mainly involving brain regions related to learning, memory and emotion, which provide early biomarkers for clarifying the mechanism of cognitive impairment and neuropsychiatric disorders in diabetes.