AUTHOR=Peng Fei , Feng Xin , He Xiaoxin , Niu Hao , Zhang Hong , Tong Xin , Zhang Baorui , Xia Jiaxiang , Chen Xuge , Xu Boya , Qi Peng , Lu Jun , Wang Daming , Liu Aihua 

TITLE=Independent predictors and risk score for intraprocedural rupture during endovascular treatment of small ruptured intracranial aneurysms (<5 mm)

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.923645

DOI=10.3389/fneur.2022.923645

ISSN=1664-2295

ABSTRACT=<sec><title>Background and purpose</title><p>Intraprocedural rupture (IPR) is a devastating complication of endovascular treatment (EVT). Small-sized and ruptured aneurysms are independent predictors of IPR, which presents a technical challenge during EVT. We aimed to develop a score to quantify the individual patient risk of IPR in the EVT of small (&lt;5 mm) ruptured aneurysms (SRAs).</p></sec><sec><title>Methods</title><p>A retrospective review was conducted to interrogate databases prospectively maintained at two academic institutions in China from January 2009 to October 2016. We collected intraoperative angiograms and medical records to identify independent predictors of IPR using univariate and multivariable analyses. A risk score for IPR was derived using multivariable logistic regression analyses.</p></sec><sec><title>Results</title><p>Of the 290 enrolled patients, IPR occurred in 16 patients (5.5%). The univariate analysis showed that the rate of IPR was significantly higher in patients having aneurysms with a small basal outpouching (SBO), in patients having aneurysms concomitant with adjacent moderate atherosclerotic stenosis (ACAMAS), and in former or current smokers. Multivariate analyses showed that SBO [odds ratio (OR): 3.573; 95% confidence interval (CI): 1.078–11.840; <italic>p</italic> = 0.037], vascular eloquence (VE; OR: 3.780; 95% CI: 1.080–13.224; <italic>p</italic> = 0.037), and ACAMAS (OR: 6.086; 95% CI: 1.768–20.955; <italic>p</italic> = 0.004) were significantly and independently associated with IPR. A three-point risk score (S-V-A) was derived to predict IPR [SBO (yes = 1), VE (yes = 1), and ACAMAS (yes = 1)].</p></sec><sec><title>Conclusions</title><p>Intraprocedural rupture occurred in 5.5% of the patients during EVT of SRA. SBO, VE, and ACAMAS were independent risk factors of IPR in the EVT of SRA. Based on these variables, the S-V-A score may be useful in predicting IPR daily, but more confirmation studies are required.</p></sec>