AUTHOR=Guo Wenting , Xu Jiali , Zhao Wenbo , Zhang Mengke , Ma Jin , Chen Jian , Duan Jiangang , Ma Qingfeng , Song Haiqing , Li Sijie , Ji Xunming 

TITLE=A nomogram for predicting malignant cerebral artery infarction in the modern thrombectomy era

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.934051

DOI=10.3389/fneur.2022.934051

ISSN=1664-2295

ABSTRACT=Objective This study aimed to develop and validate a nomogram to predict malignant cerebral artery infarction (MMI) after endovascular treatment (EVT) in patients with acute ischemic stroke (AIS) in the modern thrombectomy era.
Methods We retrospectively analyzed data from a prospective cohort of consecutive patients with AIS who underwent EVT at Xuanwu hospital between January 2013 to June 2021. A multivariable logistic regression model was employed to construct the nomogram for predicting MMI after EVT. Discrimination and calibration of the nomogram were assessed both in the derivation and validation cohorts.
Results A total of 605 patients were enrolled in this study with 425 in the derivation cohort and 180 in the validation cohort. The nomogram was developed based on admission systolic blood pressure (SBP), National Institute of Health Stroke Score (NIHSS), Alberta Stroke Program Early Computed Tomography Score (ASPECTS), vessel occlusion site, EVT time window, and recanalization status. The nomogram displayed good discrimination with the area under the receiver operating characteristics curve of 0.783 (95% confidence interval [CI], 0.726–0.840) in the derivation cohort and 0.806 (95% CI, 0.738–0.874) in the validation cohort. Calibration of the nomogram was good as well with the Hosmer-Lemeshow test of P = 0.857 in the derivation cohort and P = 0.275 in the validation cohort. 
Conclusions In the modern thrombectomy era, a nomogram containing admission SBP, NIHSS, ASPECTS, vessel occlusion site, EVT time window, and recanalization status may predict the risk of MMI after EVT in patients with AIS.