AUTHOR=Gaulee Pratima , Yang Zhihui , Sura Livia , Xu Haiyan , Rossignol Candace , Weiss Michael D. , Bliznyuk Nikolay 

TITLE=Concentration of Serum Biomarkers of Brain Injury in Neonates With a Low Cord pH With or Without Mild Hypoxic-Ischemic Encephalopathy

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.934755

DOI=10.3389/fneur.2022.934755

ISSN=1664-2295

ABSTRACT=Abstract (154 words) 
Objective – To determine the concentrations of four neuroprotein biomarkers and 68 miRNAs in neonates with low cord pH and/or mild hypoxic-ischemic encephalopathy (HIE).
Study Design – A prospective cohort study enrolled neonates with low cord pH (n=18), moderate-severe HIE (n=40), and healthy controls (n=38).  Groups provided serum samples at 0-6 h of life. The concentrations of biomarkers and miRNAs were compared between cohorts.  
Result – The low cord pH and moderate-severe HIE groups had increased concentrations of GFAP, NFL and Tau compared to controls (P<0.05, P<0.001 respectively).  NFL concentrations in mild HIE was higher than controls (P<0.05) but less than moderate-severe HIE (P<0.001). Of 68 miRNAs, 36 in low cord pH group and 40 in moderate-severe HIE were upregulated compared to controls (P<0.05). Five miRNAs in low cord pH group(P<0.05) and 3 in moderate-severe HIE were downregulated compared to controls (P<0.05).
Conclusion – A biomarker panel in neonates with low cord pH may help clinicians make real-time decisions.