AUTHOR=Yang Zhenzhen , Xu Pengfei , Geng Chaofan , Zhang Hongju 

TITLE=Evaluation of simple antioxidant blood parameters in patients with migraine

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.939363

DOI=10.3389/fneur.2022.939363

ISSN=1664-2295

ABSTRACT=Background: To investigate the roles of serum albumin (ALB), and creatinine (CRE) bilirubin (BIL) and uric acid (UA) as major intravascular antioxidants in migraine.

Methods: We enrolled 148 migraine patients, and 150 age- and sex-matched healthy controls. The serum levels of ALB, BIL, CRE and UA were measured between the two groups. The risk of migraine was assessed using multiple stepwise logistic regression analysis.

Results：The serum levels of ALB, total BIL (TBIL), CRE, and UA were significantly lower in the migraine group when compared to HCs group (p < 0.05). The ALB and UA levels were lower during migraine attack periods (p < 0.05). There were no statistically significant differences observed serum ALB, TBIL, CRE, and UA levels between aura/without aura and episodic/chronic migraine subtypes (p > 0.05). Multiple stepwise logistic regression revealed that ALB [odd ratio (OR) 0.79, 95% confidence interval (CI) 0.69-0.89, p <0.001], TBIL (OR 0.61, 95% CI 0.50-075, p <0.001), and UA (OR 0.97, 95% CI 0.96-0.99, p = 0.014) was independently associated with migraine. In addition, serum levels of ALB, TBIL, and UA were significantly lower in the migraine group when compared by sex.

Conclusion: Serum levels of UA, BIL, ALB, and CRE were lower in migraine patients, indicating a lower antioxidant status. In addition, ALB, TBIL, and UA were independently related to migraine. These results could provide insights into the possible roles of oxidative stress in the pathogenesis of migraine.