AUTHOR=Parrino Liborio , Halasz Peter , Szucs Anna , Thomas Robert J. , Azzi Nicoletta , Rausa Francesco , Pizzarotti Silvia , Zilioli Alessandro , Misirocchi Francesco , Mutti Carlotta TITLE=Sleep medicine: Practice, challenges and new frontiers JOURNAL=Frontiers in Neurology VOLUME=Volume 13 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.966659 DOI=10.3389/fneur.2022.966659 ISSN=1664-2295 ABSTRACT=Sleep medicine is an ambitious cross-disciplinary challenge, requiring the mutual integration be-tween complementary specialists in order to build a solid framework. Although knowledge in the sleep field is growing impressively thanks to technical and brain imaging support and through de-tailed clinic-epidemiologic observations, several topics are still dominated by outdated paradigms. In this review explore the main novelties and gaps in the field of sleep medicine, assess the common-est sleep disturbances, provide advices for routine clinical practice and offer alternative insights and perspectives on the future of sleep research.