AUTHOR=Huang Pan 

TITLE=Research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor TPPU on ischemic stroke

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1083972

DOI=10.3389/fneur.2023.1083972

ISSN=1664-2295

ABSTRACT=Arachidonic Acid (AA) is the precursor of cerebrovascular active substances in the human body, and its metabolites are closely related to the pathogenesis of cerebrovascular disease. The cytochrome P450 (CYP) metabolic pathway of AA is a research hotspot in recent years, and its process is regulated by soluble epoxide hydrolase (sEH). 1-Trifluoromethoxyphenyl-3(1-propionylpiperidin-4-yl)urea[1-trifluoromethoxyphenyl-3-(1-propionyl-piperidin-4-yl)urea,TPPU] is a novel The sEH inhibitor of TPPU exerts cerebrovascular protective effect by inhibiting the activity of sEH. This article reviews the mechanism of TPPU's protective effect on ischemic stroke disease.