AUTHOR=Mao Shiqi , Wu Jinhan , Yan Jingkai , Zhang Weijun , Zhu Feng 

TITLE=Dysregulation of miR-146a: a causative factor in epilepsy pathogenesis, diagnosis, and prognosis

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1094709

DOI=10.3389/fneur.2023.1094709

ISSN=1664-2295

ABSTRACT=miR-146a is an NF-κB-dependent miRNA that acts as an anti-inflammatory miRNA through the Toll-like receptor (TLR) pathway. MiR-146a targets multiple genes and has been identified to directly or indirectly regulate processes other than inflammation, including intracellular Ca changes, apoptosis, oxidative stress, and neurodegeneration. MiR-146a is an important regulator of gene expression in epilepsy development and progression. Furthermore, miR-146a-related single nucleotide polymorphisms (SNPs) and single nucleotide variants (SNVs) contribute to genetic susceptibility to drug resistance and seizure severity in epilepsy patients. This work summarizes the abnormal expression patterns of miR-146a in different types and stages of epilepsy and its potential molecular regulation mechanism, pointing out that miR-146a can be used as a novel biomarker for epilepsy diagnosis, prognosis, and treatment.