AUTHOR=Jonasson Elise , Antulov Ronald , Trøllund Pedersen Per , Sejbæk Tobias 

TITLE=Progressive multifocal leukoencephalopathy in a patient with multiple myeloma: a case report and analysis of the FDA adverse event reporting system

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1098930

DOI=10.3389/fneur.2023.1098930

ISSN=1664-2295

ABSTRACT=This paper demonstrates a case with progressive multifocal leukoencephalopathy (PML) in a patient with multiple myeloma (MM) treated with nine different MM therapies. This case report contributes to the already published 16 cases of PML in patients with MM. Additionally, we present an analysis of cases from the United States Food and Drug Administration Adverse Event Report System database (n=117) with a description of demographics and MM specific therapies.  We found, that patients with MM, that developed PML, were treated with immunomodulatory drugs (97%), alkylating agents (52%) and/or proteasome inhibitors (49%), respectively. Prior to PML diagnosis 72% of patients received two or more MM therapies. Our results indicate that PML in MM is underreported and could be related to treatment with multiple immunosuppressive therapies rather than MM as a disease itself. Physicians should be aware of potential PML in the late stage of heavily treated MM patients.