AUTHOR=Diaconu Ştefania , Irincu Laura , Ţînţ Diana , Falup-Pecurariu Cristian 

TITLE=Long-term effects of intrajejunal levodopa infusion on sleep in people with advanced Parkinson's disease

JOURNAL=Frontiers in Neurology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1105650

DOI=10.3389/fneur.2023.1105650

ISSN=1664-2295

ABSTRACT=<sec><title>Background</title><p>Sleep disturbances are commonly encountered in people with advanced Parkinson's disease (PD). In these stages, levodopa–carbidopa intestinal gel (LCIG) is recommended for improving motor symptoms, some non-motor dysfunctions, and quality of life in these patients. This study aimed to assess the effects of LCIG on sleep in PD in a longitudinal study.</p></sec><sec><title>Study design</title><p>An open-label observational study in patients with advanced PD undergoing LCIG treatment was carried out.</p></sec><sec><title>Measures and outcomes</title><p>In total, 10 consecutive advanced people with PD were evaluated at the baseline and after 6 months and 1 year, respectively, of LCIG infusion. Sleep parameters were assessed with several validated scales. We assessed the evolution of sleep parameters under LCIG infusion over time and the effects on sleep quality.</p></sec><sec><title>Results</title><p>Significant improvement following LCIG was observed in PSQI total score (<italic>p</italic> = 0.007), SCOPA-SLEEP total score (<italic>p</italic> = 0.008), SCOPA-NS subscale (<italic>p</italic> = 0.007), and AIS total score (<italic>p</italic> = 0.001) at 6 months and 1 year, compared to the baseline. The PSQI total score at 6 months correlated significantly with the Parkinson's Disease Sleep Scale, version 2 (PDSS-2) “disturbed sleep” item at 6 months (<italic>p</italic> = 0.28; <italic>R</italic> = 0.688), while the PSQI total score at 12 months significantly correlated with the PDSS-2 total score at 1 year (<italic>p</italic> = 0.025, <italic>R</italic> = 0.697) and with the AIS total score at 1 year (<italic>p</italic> = 0.015, <italic>R</italic> = 0.739).</p></sec><sec><title>Conclusion</title><p>LCIG infusion demonstrated beneficial effects on sleep parameters and sleep quality, which were constant over time for up to 12 months.</p></sec>