AUTHOR=Zhang Sirui , Lin Junyu , Cheng Yangfan , Hou Yanbin , Shang Huifang 

TITLE=Aberrant resting-state brain activity in Huntington's disease: A voxel-based meta-analysis

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1124158

DOI=10.3389/fneur.2023.1124158

ISSN=1664-2295

ABSTRACT=Functional neuroimaging could provide abundant information of underling pathophysiological mechanisms of the clinical triad including motor, cognitive and psychiatric impairment in Huntington’s Disease (HD). We performed a voxel-based meta-analysis using anisotropic effect size‐signed differential mapping (AES‐SDM) method and included 6 studies (78 symptomatic HD, 102 premanifest HD and 131 healthy controls) in total. Altered resting-state brain activity was primarily detected in the bilateral medial part of superior frontal gyrus, bilateral anterior cingulate / paracingulate gyrus, left insula, left striatum, right cortico-spinal projections area, right inferior temporal gyrus area, right thalamus, right cerebellum and right gyrus rectus area. Premanifest and symptomatic HD patients showed different alterative pattern in the subgroup analyses. The robust and consistent abnormalities in the specific brain regions identified in the current study could help to understand the pathophysiology of HD and explore reliable neuroimaging biomarkers for monitoring disease progression, or even predicting the onset of premanifest HD patients.