AUTHOR=Zhou Jingyi , Wang Rui , Mao Jizhong , Gu Yichen , Shao Anwen , Liu Fengqiang , Zhang Jianmin 

TITLE=Prognostic models for survival and consciousness in patients with primary brainstem hemorrhage

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1126585

DOI=10.3389/fneur.2023.1126585

ISSN=1664-2295

ABSTRACT=Objectives: Primary brainstem hemorrhage (PBSH) is one of the most catastrophic spontaneous intracerebral hemorrhage diseases, with a mortality rate of 70-80%. We explored the predictive factors for survival and consciousness in patients with PBSH (ClinicalTrials.gov ID: NCT04910490).
Methods: We retrospectively reviewed 211 patients with PBSH admitted to our institution between January 2014 and October 2020. Clinical outcomes included the 30-day survival rate and the 90-day consciousness rate as evaluated by the National Institutes of Health Stroke Scale score. Multiple logistic regression analysis was performed. 
Results: The overall 30-day survival rate of 211 patients with PBSH was 70%. Several predictive factors, including hematoma volume, hematoma location, activated partial thromboplastin time (APTT) upon admission, and therapeutic strategy, were significantly related to 30-day survival. Compared with conservative treatment, stereotactic aspiration in our prediction model is strongly associated with improved 30-day survival (odds ratio, 6.67; 95% confidence interval, 3.13-14.29; P < 0.001). The prognosis prediction model of 90-day consciousness, including factors such as mydriasis, APTT value, hematoma location, and hematoma volume upon admission, has a good predictive effect (AUC, 0.835; 95% confidence interval, 0.78-0.89; P < 0.001).
Conclusion: In patients with PBSH, conscious state upon admission, coagulation function, hematoma volume, hematoma location, and therapeutic strategy were significantly associated with prognosis. Stereotactic aspiration could significantly reduce the 30-day mortality rate.