AUTHOR=Shi Fanfan , Sha Leihao , Li Hua , Tang Yusha , Huang Litao , Liu Huizhen , Li Xu , Li Lin , Yang Wenjie , Kang Deying , Chen Lei 

TITLE=Recent progress in patent foramen ovale and related neurological diseases: A narrative review

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1129062

DOI=10.3389/fneur.2023.1129062

ISSN=1664-2295

ABSTRACT=Patent foramen ovale (PFO) is a common congenital cardiac abnormality when the physiological channel of atrioventricular septal is not closed at adulthood. This abnormality affects 25% of the general population. With development of precision medicine, an increasing number of clinical studies have reported that PFO is closely related to various neurological diseases such as stroke, migraine, obstructive sleep apnea, and decompression syndrome. It has also been suggested that PFO closure could be effective for treating these neurological diseases. Therefore, increasing attention has been given to the prevention, diagnosis, and treatment of PFO-related neurological diseases. This article reviewed and discussed the pathogenesis, epidemiology and clinical characteristics of PFO-related neurological diseases, as well as the treatment of different neurological diseases. By reviewing existing literature, this paper aims to provide current progress for this field and decision-making evidence for clinical practice.