AUTHOR=Gentina Thibaut , Gentina Elodie , Douay Bernard , Micoulaud-Franchi Jean-Arthur , Pépin Jean-Louis , Bailly Sébastien TITLE=Investigating associations between social determinants, self-efficacy measurement of sleep apnea and CPAP adherence: the SEMSA study JOURNAL=Frontiers in Neurology VOLUME=Volume 14 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1148700 DOI=10.3389/fneur.2023.1148700 ISSN=1664-2295 ABSTRACT=Study Objectives: The prospective Self-Efficacy Measure for Sleep Apnea study (SEMSAS) is investigating thresholds for health literacy, self-efficacy and precariousness at obstructive sleep apnea (OSA) diagnosis to predict CPAP adherence. This paper describes the study protocol and presents baseline data from the ongoing study. Methods: Eligible individuals had confirmed OSA and were referred to a homecare provider for continuous positive airway pressure (CPAP) therapy initiation. Data on patient characteristics and comorbidities were collected, along with baseline evaluations of self-efficacy (15-item Self-Efficacy Measure for Sleep Apnea tool [SEMSA-15]), precariousness (Deprivation in Primary Care Questionnaire [DipCareQ]), and health literacy (Health Literacy Questionnaire). CPAP adherence over 12 months of follow-up will be determined using remote monitoring of CPAP device data. The primary objective is to define an optimal SEMSA-15 score threshold to predict CPAP adherence at 3- and 12-month follow-up. Results: Enrollment of 302 participants (71% male, median age 55 years, median body mass index 31.6 kg/m2) is complete. Low self-efficacy (SEMSA-15 score ≤2.78) was found in 93/302 participants (31%), and 38 (12.6%) reported precariousness (DipCareQ score >1); precariousness did not differ significantly between individuals with a SEMSA-15 score ≤2.78 versus >2.78. Health literacy was generally good, but was significantly lower in individuals with versus without precariousness, and with low versus high self-efficacy. Conclusions: SEMSAS is the first study using multidimensional baseline assessment of self-efficacy, health literacy and precariousness, plus other characteristics, to determine future adherence to CPAP, including CPAP adherence trajectories. Collection of follow-up data is underway.