AUTHOR=Geng Yibo , Jia Jianwen , Liu Xiaoli , Li Tong , Liu He , Sun Yongquan , Wang Yang 

TITLE=Clinical outcome and prognostic factors of patients with non-traumatic angiography-negative subarachnoid hemorrhage

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1157845

DOI=10.3389/fneur.2023.1157845

ISSN=1664-2295

ABSTRACT=Purpose: The cause of spontaneous subarachnoid hemorrhage (SAH) is unknown in 10% of cases. The aim of this study was to demonstrate the characteristics of patients with angiography-negative subarachnoid hemorrhage (anSAH) and to analyze factors influencing the clinical outcome in patients suffering from anSAH. Methods: A retrospective cohort of 75 patients with anSAH (26 perimesencephalic (pmSAH) and 49 non-perimesencephalic SAH (npmSAH))admitted between January 2016 and June 2022 was included. We analyzed demographic, clinical data and 6-month functional outcomes. Enter regression analysis was performed to identify factors associated with outcomes.Results: Unfavorable outcome was achieved in 10 of 75 patients (13.3%).Unfavorable outcome was associated with senior adults (P = 0.008), Hijdra cistern score (HCS) elevation (P = 0.015), long-time lumbar cistern continuous drainage (LCFD) (P = 0.029) and hydrocephalus (P = 0.046). The only significant risk factor for unfavorable outcome after npmSAH was the HCS (OR 1.213 (95%CI 1.007-1.462), P = 0.042).Our study provides valuable information on both SAH patterns and functional outcome in patients suffering from anSAH and should be taken into consideration during management of these patients.