AUTHOR=Xie Fangfang , Mao Ting , Tang Jingyi , Zhao Linmei , Guo Jiuqing , Lin Huashan , Wang Dongcui , Zhou Gaofeng 

TITLE=Evaluation of iron deposition in the motor CSTC loop of a Chinese family with paroxysmal kinesigenic dyskinesia using quantitative susceptibility mapping

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1164600

DOI=10.3389/fneur.2023.1164600

ISSN=1664-2295

ABSTRACT=Introduction: Previous studies have revealed structural, functional and metabolic changes in brain regions inside cortico-striatal-thalamo-cortical (CSTC) loop in patients with paroxysmal kinesigenic dyskinesia (PKD), whereas none quantitative susceptibility mapping (QSM) related studies have explored brain iron deposition in these areas.
Methods: A total of eight familial PKD patients and ten of their healthy family members (normal controls) were recruited and underwent QSM on a 3T magnetic resonance imaging system. Magnetic susceptibility maps were reconstructed using a Multi-Scale Dipole Inversion algorithm. Then we specifically analyzed changes of local mean susceptibility values in cortical regions and subcortical nuclei inside the motor CSTC loop. 
Results: Compared with normal controls, PKD patients had altered brain iron levels. In the cortical gray matter area involved with the motor CSTC loop, susceptibility values were generally elevated, especially in the bilateral M1 and PMv regions. In the subcortical nuclei regions involved with the motor CSTC loop, susceptibility values were generally lower, especially in the bilateral substantia nigra regions.
Conclusions: Our results provide new evidence for the neuropathogenesis of PKD and suggest that an imbalance in brain iron levels may play a role in PKD.