AUTHOR=Shen Ruihuan , Wang Jia , Tian Yuqing , Wang Rui , Guo Peiyao , Shen Shuhui , Liu Donghao , Zou Tong 

TITLE=Association between hysterectomy status and stroke risk and cause-specific and all-cause mortality: evidence from the 2005–2018 National Health and Nutrition Examination Survey

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1168832

DOI=10.3389/fneur.2023.1168832

ISSN=1664-2295

ABSTRACT=BACKGROUND: Prior research on women who had hysterectomies have shown mixed results on whether or not hysterectomies increased the incidence of stroke and cause-specific or all-cause mortality.
METHODS: Utilizing information from the Continuous National Health and Nutrition Examination Survey (NHANES) in the United States, including linked mortality follow-up files available for public access, a multicycle cross-sectional design and mortality linkage study was performed. 
RESULTS: During the years 2005-2018, the study sample included 14214 female participants ranging in age from 20 to 85. The relationship between the hysterectomy status and the risk of stroke and cause-specific and all-cause mortality was examined using a series of weighted Logistic regressions and Cox proportional hazards regressions, respectively. The presence of a hysterectomy was consistently linked to an elevated risk of stroke using weighted logistic regression models. The hysterectomy status, however, was consistently shown to have no effect on survival by adjusted weighted Cox regression analysis.
CONCLUSIONS: Our study found a significant association between having undergone a hysterectomy and having experienced a stroke, even after adjusting for other factors that could impact risk, such as the American Heart Association (AHA)’s Life's Simple 7 cardiovascular health score and variables of age, ethnicity, marital status, income, education, and depression severity.