AUTHOR=Li XiuLi , Huang FuBiao , Guo TieJun , Feng MengChen , Li Shan 

TITLE=The continuous performance test aids the diagnosis of post-stroke cognitive impairment in patients with right hemisphere damage

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1173004

DOI=10.3389/fneur.2023.1173004

ISSN=1664-2295

ABSTRACT=This study analyzed the time course of relative changes in oxygenated hemoglobin (Oxy-Hb) concentrations in the prefrontal cortex (PFC) during the continuous performance test (CPT) between controls and patients with post-stroke cognitive impairment (PSCI) who had right hemisphere damage (RHD). It also explored the mechanism of neural compensation in these cases. A total of 16 patients with RHD (RHD group) and 32 normal subjects (control group) were recruited. The Montreal Cognitive Assessment Scale was used to assess post-stroke cognitive damnification. Functional nearinfrared spectroscopy and the CPT were employed to investigate task-related changes in Oxy-Hb levels. The RHD group showed significantly lower correct detection and hit rates than the control group; however, the average reaction time was significantly longer in the former. Although the two groups showed no statistically significant difference in terms of left and right PFC integral values, the mean values were greater in the RHD group. The centroid value of the right PFC was significantly higher in the RHD group than in the control group. The time course of Oxy-Hb concentrations in the PFC differed between the two groups. In the RHD group, neural compensation was observed in both prefrontal lobes; however, the rate of compensation was slower on the affected side. The CPT may be helpful in the clinical diagnosis of PSCI with RHD. It may therefore be used to evaluate the effectiveness of cognitive interventions.