AUTHOR=Cao Ying , Sun Yang , Liu Xiao , Yu Kang , Gao Danyang , Yang Jiaojiao , Miao Huihui , Li Tianzuo 

TITLE=A bibliometric analysis of the neurotoxicity of anesthesia in the developing brain from 2002 to 2021

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1185900

DOI=10.3389/fneur.2023.1185900

ISSN=1664-2295

ABSTRACT=Background: The neurotoxicity effects of anesthetic exposure on the developing brain have been one of the current research hotspots and increasing articles were published in the past decades. However, the quality and comparative information of these articles have not been reported. This research aimed to provide a comprehensive overview of the current state of the field by investigating research hotspots and publication trends concerning the neurotoxicity of anesthesia in the developing brain.
Materials and methods: On June 15, 2022, we searched articles on neurotoxicity of anesthesia in developing brain through the Science Citation Index databases from 2002 to 2021. Author, title, publication, funding agency, date of publication, abstract, type of literature, country, journal, keywords, number of citations and research direction were among the details gathered for further analysis.
Results: We searched and analyzed 414 articles in English on the field of neurotoxicity of anesthesia in the developing brain from 2002 to 2021. The country with the largest number of publications was The United States (US) (n = 226), which also had the largest total number of citations (10,419). Research in this field reached a small peak in 2017. And the largest number of articles were published in three journals, Anesthesiology, Anesthesia and Analgesia and Pediatric Anesthesia. The top 20 papers that were cited the most often were studied. In addition, the top hotspots of this area in clinical investigations and basic research were analyzed separately.
Conclusion: This study provided an overview of development in neurotoxicity of anesthesia in the developing brain using bibliometric analysis. Current clinical studies in this area were mainly retrospective, in the future, we should place more emphasis on prospective, multicenter, long-term monitoring clinical studies. More basic research was also needed on the mechanisms of neurotoxicity in anesthesia in the developing brain.