AUTHOR=Yang Rong , Li Zheng , Xu Jing , Luo Juan , Qu Zhichuang , Chen Xin , Yu Sixun , Shu Haifeng 

TITLE=Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1198546

DOI=10.3389/fneur.2023.1198546

ISSN=1664-2295

ABSTRACT=Hypoxia is characterized by low oxygen levels in the body or environment, resulting in various physiological and patholog-ical changes. The brain, which has the highest oxygen con-sumption of any organ, is particularly susceptible to hypoxic injury. Exposure to low-pressure hypoxic environments can cause irreversible brain damage. Hypoxia can occur in healthy individuals at high altitudes or in pathological condi-tions such as trauma, stroke, inflammation, and autoimmune and neurodegenerative diseases, leading to severe brain damage and impairments in cognitive, learning, and memory functions. Exosomes may play a role in the mechanisms of hypoxic injury and adaptation and are a current focus of re-search. Investigating changes in exosomes in the central nervous system under hypoxic conditions may aid in pre-venting secondary damage caused by hypoxia. This paper provides a brief overview of central nervous system injury resulting from hypoxia, with particular emphasis on high-altitude hypoxic injury. This review aimed to investigate the role and mechanism of exosomes in craniocerebral injury caused by hypoxia.