AUTHOR=Zhou Rui , Chen Shenjian , Luo Qinghua , Zhang Xinyue , Li Fang , Huang Wei , Sheng Zhiyong 

TITLE=Case report: COVID-19-associated refractory thrombotic thrombocytopenic purpura complicated with Guillain-Barré syndrome

JOURNAL=Frontiers in Neurology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1199889

DOI=10.3389/fneur.2023.1199889

ISSN=1664-2295

ABSTRACT=Thrombotic thrombocytopenic purpura (TTP), a rare and lethal thrombotic microangiopathy, is an autoimmune disease that can be triggered by viral infections such as COVID-19. It is characterized by hemolytic microangiopathy, thrombocytopenia, neurologic alterations, and possibly in conjunction with fever and renal damage. Moreover, more than 220 patients with Guillain-Barré syndrome (GBS) have been reported associated with COVID-19 infection. Here, we report a patient who presented with refractory TTP complicated by GBS following SARS-CoV-2 infection. We aim to highlight the precise diagnosis of neurological complications associated with COVID-19 infection and to illustrate the experience of successfully treating a patient with COVID-19 infection-related refractory TTP complicated by GBS.